Fragment-based approaches in drug discovery /
| Corporate Author: | |
|---|---|
| Other Authors: | , |
| Format: | eBook |
| Language: | English |
| Published: |
Weinheim :
Wiley-VCH,
[2006]
|
| Series: | Methods and principles in medicinal chemistry ;
34. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- The concept of fragment-based drug discovery / Daniel A. Erlanson and Wolfgang Jahnke
- Multivalency in ligand design / Vijay M. Krishnamurthy, Lara A. Estroff, and George M. Whitesides
- Entropic consequences of linking ligands / Christopher W. Murray and Marcel L. Verdonk
- Location of binding sites on proteins by the multiple solvent crystal structure method / Dagmar Ringe and Carla Mattos
- Cheminformatics approaches to fragment-based lead discovery / Tudor I. Oprea and Jeffrey M. Blaney
- Structural fragments in marketed oral drugs / Michal Vieth and Miles Siegel
- Fragment docking to proteins with the multi-copy simultaneous search methodology / Collin M. Stultz and Martin Karplus
- NMR-guided fragment assembly / Daniel S. Sem
- SAR by NMR : an analysis of potency gains realized through fragment-linking and fragment-elaboration strategies for lead generation / Philip J. Hajduk, Jeffrey R. Huth, and Chaohong Sun
- Pyramid : an integrated platform for fragment-based drug discovery / Thomas G. Davies, Rob L. M. van Montfort, Glyn Williams, and Harren Jhoti
- Fragment-based lead discovery and optimization using X-ray crystallography, computational chemistry, and high-throughput organic synthesis / Jeff Blaney, Vicki Nienaber, and Stephen K. Burley
- Synergistic use of protein crystallography and solution-phase NMR spectroscopy in structure-based drug design : strategies and tactics / Cele Abad-Zapatero, Geoffrey F. Stamper, and Vincent S. Stoll
- Ligand SAR using electrospray ionizing mass spectrometry / Richard H. Griffey and Eric E. Swayze
- Tethering / Daniel A. Erlanson, Marcus D. Ballinger, and James A. Wells
- Click chemistry for drug discovery / Stefanie Röper and Hartmuth C. Kolb
- Dynamic combinatorial diversity in drug discovery / Matthias Hochgürtel and Jean-Marie Lehn.