Conditional mutagenesis : an approach to disease models /

Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Abuin, A., Feil, Robert, Metzger, Daniel
Format: eBook
Language:English
Published: Berlin ; New York : Springer, [2007]
Series:Handbook of experimental pharmacology. v. 178.
Subjects:
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Conditional somatic mutagenesis in the mouse using site-specific recombinases
  • Cre/loxP-mediated chromosome engineering of the mouse genome
  • Tetracycline-controlled genetic switches
  • Novel gene switches
  • Improved embryonic stem cell technologies
  • Gene trap mutagenesis
  • RNA interference in mice
  • Viral vectors: a wide range of choices and high levels of service
  • Conditional mutagenesis by cell-permeable proteins: potential, limitations and prospects
  • Analysis of mouse development with conditional mutagenesis
  • Conditional mouse models of cancer
  • Conditional mutagenesis reveals immunological functions of widely expressed genes: activation thresholds, homeostatic mechanisms and disease models
  • Conditional transgenesis and recombination to study the molecular mechanisms of brain plasticity and memory
  • A novel conditional knockout strategy applied to serotonin receptors
  • Conditional mouse models for Friedreich Ataxia, a neurodegenerative disorder associating cardiomyopathy
  • Animal models in cardiovascular diseases: new insights from conditional models
  • Conditional animal models for the study of lipid metabolism and lipid disorders
  • Conditional mouse models to study developmental and pathophysiological gene function in muscle
  • Analysis of calcuim channels by conditional mutagenesis
  • Conditional mutagenesis of G-protein coupled receptors and G-proteins
  • Contribution of targeted conditional somatic mutagenesis to deciphering retinoid X receptor functions and to generating mouse models of human diseases.