rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Characterizing strain in the proximal rat tibia during electrical muscle stimulation
  name:
    name part: Vyvial, Brent Aron
    name part: 1980-
    role:
      role term: creator
  name:
    name part: Bloomfield, Susan A.
    role:
      role term: thesis advisor.
  name:
    name part: Hogan, Harry A.
    role:
      role term: thesis advisor.
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: txu
    date issued: 2007
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: remote
  abstract: Hindlimb unloading is a widely used model for studying the effects of microgravity on a skeleton. Hindlimb unloading produces a marked loss in bone due to increased osteoclast activity. Electrical muscle stimulation is being investigated as a simulated resistive exercise countermeasure to attenuate this bone loss. I sought to determine the relationship between strain measured at the antero-medial aspect of the proximal diaphysis of tibia and plantar-flexor torque measured at the ankle during electrical muscle stimulation as an exercise countermeasure for hindlimb unloading in rats. A mathematical relationship between strain and torque was established for the exercise during a 28 day period of hindlimb unloading. The strain generated during the exercise protocol is sufficient to attenuate bone loss caused by hindlimb unloading. Twelve six-month old Sprague-Dawley rats were implanted with uni-axial strain gages in vivo on the antero-medial aspect of the proximal diaphysis of the left tibia. Strain and torque were measured during electrical muscle stimulation for three time points during hindlimb unloading (Day 0 (n=3), Day 7 (n=3), Day 21 (n=3)). Peak strain decreased from 1,100 μstrain at the beginning of the study to 660 μstrain after 21 days of hindlimb unloading and muscle stimulation. The peak strain rate measured during muscle stimulation was 10,350 μstrain/second at the beginning and decreased to 6,670 μstrain/second after 21 days. The changes in strain are not significant, but the underlying trend in strain values may indicate an increase in bone formation due to the electrical muscle stimulation countermeasure. A mathematical model that relates measured strain to peak eccentric torque during muscle stimulation was created to facilitate estimation of strain for future studies of electrical muscle stimulation during hindlimb unloading.
  note: by Brent Aron Vyvial.
  note: "Major Subject: Mechanical Engineering"
  note: Title from author supplied metadata (automated record created on Nov. 2, 2007.)
  note: Vita.
  note: Abstract.
  note: Electronic resource.
  note: Mode of access: World Wide Web.
  note: System requirements: World Wide Web access and Adobe Acrobat Reader.
  note: M. S. Texas A&M University 2006.
  note: Includes bibliographical references.
  note: Text (Thesis).
  subject:
    topic: Major mechanical engineering
  subject:
    topic: biomechanics
  subject:
    topic: aging male rats
  subject:
    topic: bone
  subject:
    topic: space
  identifier: http://hdl.handle.net/1969.1/5760
  record info:
    record content source: TXA
    record creation date: 080130
    record change date: 20151108072107.0
    record identifier: in00002346685