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Characterizing strain in the proximal rat tibia during electrical muscle stimulation
Hindlimb unloading is a widely used model for studying the effects of microgravity on a skeleton. Hindlimb unloading produces a marked loss in bone due to increased osteoclast activity. Electrical muscle stimulation is being investigated as a simulated resistive exercise countermeasure to attenuate this bone loss. I sought to determine the relationship between strain measured at the antero-medial aspect of the proximal diaphysis of tibia and plantar-flexor torque measured at the ankle during electrical muscle stimulation as an exercise countermeasure for hindlimb unloading in rats. A mathematical relationship between strain and torque was established for the exercise during a 28 day period of hindlimb unloading. The strain generated during the exercise protocol is sufficient to attenuate bone loss caused by hindlimb unloading. Twelve six-month old Sprague-Dawley rats were implanted with uni-axial strain gages in vivo on the antero-medial aspect of the proximal diaphysis of the left tibia. Strain and torque were measured during electrical muscle stimulation for three time points during hindlimb unloading (Day 0 (n=3), Day 7 (n=3), Day 21 (n=3)). Peak strain decreased from 1,100 μstrain at the beginning of the study to 660 μstrain after 21 days of hindlimb unloading and muscle stimulation. The peak strain rate measured during muscle stimulation was 10,350 μstrain/second at the beginning and decreased to 6,670 μstrain/second after 21 days. The changes in strain are not significant, but the underlying trend in strain values may indicate an increase in bone formation due to the electrical muscle stimulation countermeasure. A mathematical model that relates measured strain to peak eccentric torque during muscle stimulation was created to facilitate estimation of strain for future studies of electrical muscle stimulation during hindlimb unloading.
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