Two new, single-isomer, sulfated [beta]-cyclodextrins for use as chiral resolving agents for enantiomer separations in capillary electrophoresis /
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| Format: | Thesis eBook |
| Language: | English |
| Published: |
[College Station, Tex.] :
[Texas A&M University],
[2006]
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| Online Access: | Link to OAK Trust copy |
| Abstract: | Two novel, single-isomer, sulfated cyclodextrins, the sodium salts of heptakis (2-O-methyl-3-O-acetyl-6-O-sulfo) cyclomaltoheptaose (HMAS) and heptakis(2-O-methyl-6-O-sulfo)cyclomaltoheptaose (HMS) were used as chiral resolving agents in both aqueous and non-aqueous electrophoretic separation of a set of pharmaceutically active weak base enantiomers. Enantiomers of twenty one of the twenty four weak bases were baseline resolved in one or more of the background electrolytes (BGE's) used. An eight-step synthetic method was used to produce, on a large scale, the title compounds in greater than 97% purity. The purity of the synthetic intermediates and the final products were characterized by HPLC-ELSD and indirect UV-detection capillary electrophoresis (CE), respectively. X-ray crystallography, MALDI-TOF masss pectrometry and ¹H as well as ¹³C NMR spectroscopy allowed for unambiguous characterization of the structure of each intermediate and the final product. |
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| Item Description: | "Major Subject: Chemistry" Title from author supplied metadata (automated record created on Sep. 15, 2006.) Vita. Abstract. Electronic resource. |
| Format: | Mode of access: World Wide Web. System requirements: World Wide Web access and Adobe Acrobat Reader. |
| Bibliography: | Includes bibliographical references. |