Table of Contents:
  • Introduction: Drug discovery in the 21st century / Shayne Cox Gad
  • Natural products / Charles B. Spainhour
  • Cancer cell proteomics using molecular aptamers / Weihong Tan ... [et al.]
  • Molecular similarity methods and QSAR models as tools for virtual screening / Jürgen Bajorath
  • Systems biology: applications in drug discovery / Sean Ekins ...[et al.]
  • High throughput flow cytometry / Larry A. Sklar ... [et al.]
  • Combining NMR spectral information with associated structural features to form computationally nonintensive, rugged, and objective models of biological activity / Richard D. Beger, Dan A. Buzatu, and Jon G. Wilkes
  • Using Microsoft Excel as a laboratory data management tool / A. Erik Rubin, Mark F. Russo, and William Neil
  • Age of regulation / Sandy Weinberg and Gerald J. Whartenby
  • Simultaneous screening of multiple cell lines using the CellCard system / Oren E. Beske
  • Protein X-ray crystallography in drug discovery / Peter Nollert ... [et al.]
  • Biological and chemistry assays available during drug discovery and developability assessment / Duane B. Lakings
  • Strategies and methods in monitoring and targeting protein-protein interactions / Arianna Loregian and Giorgio Palù
  • High-throughput screening: evolution of technology and methods
  • Martyn N. Banks ... [et al.]
  • Metal-enhanced fluorescence: application to high-throughput screening and drug discovery / Kadir Aslan ... [et al.]
  • Methods for the design and analysis of replicate-experiment studies to establish assay reproducibility and the equivalence of two potency assays / Brian J. Eastwood ... [et al.]
  • Coupled luminescent methods in drug discovery: 3-minute assays for cytotoxicity and phosphatase activity / Michael J. Corey and Robert J. Kinders
  • Design and pharmaceutical applications of prodrugs / Tomi Järvinen ... [et al.]
  • GABA and glutamate receptor ligands and their therapeutic potential in CNS disorders / Ulf Madsen ... [et al.]
  • Cardiac sarcolemmal ATP-sensitive potassium channel antagonists: novel ischemia-selective antiarrhythmic agents / George E. Billman
  • Factors influencing the efficacy of mediator-specific anti-inflammatory, glucocorticoid, and anticoagulant therapies for sepsis / Peter C. Minneci ... [et al.]
  • Combinatorial chemistry in the drug discovery process / Nathan T. Ross, Brian R. McNaughton, and Benjamin L. Miller
  • Herbal medicines and animal models of gastrointestinal diseases / C.H. Cho and J.K.S. Ko
  • Endocrine and metabolic agents / Brian L. Furman
  • Respiratory viruses / Paul D. Olivo
  • Strategies in the design of antiviral drugs / Erik De Clercq and Piet Herdewijn
  • Protein kinase inhibitors in drug discovery / Keykavous Parang and Gongqin Sun
  • RNA-based therapies / Steve Pascolo
  • Novel imaging agents for molecular MR imaging of cancer / Dmitri Artemov and Zaver M. Bhujwalla
  • Targets and approaches for cancer drug discovery / Susan L. Mooberry.