N₂S₂ chelating agents as Cys-X-Cys biomimics for Fe(NO) and Fe(NO)₂ complexes /
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| Other Authors: | |
| Format: | Thesis eBook |
| Language: | English |
| Published: |
[College Station, Tex.] :
[Texas A&M University],
[2006]
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| Subjects: | |
| Online Access: | Link to OAK Trust copy |
| Abstract: | Nitric oxide plays an important role in many biological functions. A metallo derivative in biological systems is a protein-bound dinitrosyl iron complex (DNIC), which results from iron-sulfur cluster degradation in the presence of excess NO. Through model complexes I have examined the fundamental properties of a dithiolato-Fe(NO)₂ complex, bismercaptoethandiazacyclooctane iron dinitrosyl or (H⁺bme-daco)Fe(NO)₂ as a biomimic of dicysteinate coordination of [Fe(NO)₂]. This complex was prepared and fully characterized in my studies. The DNIC moiety is in its oxidized state, {Fe(NO)₂}⁹. Through reaction studies, monitored by IR spectroscopy (H⁺N₂S₂)Fe(NO)₂ (N₂S₂ = bme-dach. Bme-pda) has been shown to transfer NO to Fe[superscript]III in (TPP)FeCl (TPP = meso-tetraphenylporphyrin) as NO⁻. The remaining mononitrosyl converts into complex (N₂S₂)Fe(NO). The (N₂S₂)Fe(NO) complexes (N₂S₂ = bme-daco, bme*-daco, bme-dach) were prepared by direct reaction of dimeric [(N₂S₂)Fe]₂ and NO gas. The analogous (N₂S₂)Co(NO) complex (N₂S₂ = bme-dach) has also been prepared. The series of square pyramidal (N₂S₂)M(NO) have been studied by cyclic voltammetry and v(NO) IR spectroscopy. |
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| Item Description: | "Major Subject: Chemistry" Title from author supplied metadata (automated record created on Sep. 15, 2006.) Vita. Abstract. Electronic resource. |
| Format: | Mode of access: World Wide Web. System requirements: World Wide Web access and Adobe Acrobat Reader. |
| Bibliography: | Includes bibliographical references. |