Multiple analyses in clinical trials : fundamentals for investigators /

One of the most challenging issues for clinical trial investigators, sponsors, and regulatory officials is the interpretation of experimental results that are composed of the results of multiple statistical analyses. These analyses may include the effect of therapy on multiple endpoints, the assessm...

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Bibliographic Details
Main Author:	Moyé, Lemuel A.
Corporate Author:	SpringerLink (Online service)
Format:	eBook
Language:	English
Published:	New York : Springer, [2003]
Series:	Statistics for biology and health.
Subjects:	Clinical trials. Multivariate analysis. Clinical trials > Statistical methods. Research Design. Clinical Trials as Topic > methods. Multivariate Analysis. Statistics for Life Sciences, Medicine, Health Sciences. Medicine/Public Health, general. MEDICAL > Biostatistics. Electronic books.
Online Access:	Connect to the full text of this electronic book Connect to the full text of this electronic book

Table of Contents:

Introduction
The Rudiments: Methodologic Roots of Clinical Trial Design
Multiple Analyses and the Random Experiment
The Lure and Complexity of Multiple Analyses
Multiple Analyses and Multiple Endpoints
Introduction to Multiple Dependent Analyses
Multiple Dependent Analyses 2
Introduction to Composite Endpoints
Multiple Analyses and Composite Endpoints
Introduction to Subgroup Analyses
Subgroups II: Effect Domination and Controversy
Subgroups III: Confirmatory Analyses
Multiple Analyses and Multiple Treatment Arms
Combining Multiple Analyses
Conclusions.