rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Presynaptic mechanisms of ethanol
    sub title: role of the microtubule and actin cytoskeleton in ethanol's inhibition of dopamine release
  name:
    name part: Reiter, Cindy Kay.
    role:
      role term: creator
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: xx
    date issued: 2003
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    extent: xi, 129 leaves : illustrations ; 28 cm.
  abstract: Alcohol abuse is the third leading cause of premature death in the United States. However, the cellular mechanisms, primarily the presynaptic mechanisms, underlying addiction remain unclear. A central question in the complex field of alcohol addiction concerns identifying the proteins that are involved in alcohol reinforcement, tolerance, and relapse. Importantly, one characteristic of all drugs of abuse, including alcohol, is the release of dopamine in an area of the brain called the nucleus accumbens. Increases in dopamine in the nucleus accumbens appear to mediate the "rewarding" aspect of drug addiction. Alcohol, like other addictive drugs, has been shown to stimulate dopamine release in the nucleus accumbens when administered acutely while chronic exposure can result in a "tolerance" to the acute effects. We have found that chronic ethanol exposure inhibits several forms of stimulated-dopamine release. Thus, we hypothesized that ethanol may alter general neurotransmitter release processes. The overall goal of the following study was to investigate the effects of chronic ethanol on specific neurotransmitter release proteins and cytoskeleton proteins involved in exocytosis. We investigated the role of the microtubule-transport system in ethanol's inhibition of neurotransmitter release. The results of these studies indicted that disruption of the microtubule-associated transport is unlikely to mediate ethanol's inhibition of neurotransmitter release. However, using several independent assays we found that chronic ethanol inhibits other important steps in neurotransmitter release. In order for neurotransmitter release to ensue under sustained stimulation, vesicles which are anchored in the presynaptic actin cytoskeleton must be released and moved from the reserve pool to the ready releasable pool near the nerve terminal membrane. We show that chronic ethanol appears to inhibit the refilling of the ready releasable pool of synaptic vesicles by inhibiting the breakdo…
  note: by Cindy Kay Reiter.
  note: Vita.
  note: "Major Subject: Medical Sciences".
  note: Issued also on microfiche from University Microfilm Inc.
  note: Ph. D. Texas A&M University 2003
  note: Includes bibliographical references (leaves 108-128).
  subject:
    topic: Major medical sciences
  identifier: 31-01559 UMI
  identifier: http://proxy.library.tamu.edu/login
  related item:
    location:
      url: http://proxy.library.tamu.edu/login
  record info:
    record content source: TXA
    record creation date: 040927
    record change date: 20190326101720.0
    record identifier: in00001997492