rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Associative tolerance to nicotine's analgesic effects
    sub title: studies on number of conditioning trials and corticosterone
  name:
    name part: Davis, Kristina
    name part: 1974-
    role:
      role term: creator
  name:
    name part: Cepeda-Benito, Antonio
    role:
      role term: thesis advisor.
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: txu
    date issued: 2003
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource.
  abstract: This study examined the number of conditioning trials necessary to produce associative nicotine tolerance and the changes in corticosterone levels during the procedures. Six independent groups of rats (N = 355) were run through tolerance acquisition procedures for 1, 5, or 10 conditioning sessions. Treatment groups were comprised of animals that received nicotine-environment pairings, animals that received nicotine explicitly unpaired with the drug administration environment, and control groups that received either saline throughout or no treatment. Three of the groups were tested for nicotine-induced analgesia using the tail-flick and hot-plate assays, and three groups were blood sampled after either nicotine or saline injection. Pairing of environment with nicotine produced greater tolerance for rats after 5 conditioning sessions in the tail flick and after 10 conditioning sessions in the hot-plate. Corticosterone levels were elevated in all rats given nicotine. Rats that received the nicotine-environment pairing showed a conditioned release of corticosterone in response the environment after both 5 and 10 conditioning sessions.
  note: by Kristina Davis.
  note: "Major Subject: Psychology"
  note: Title from author supplied metadata.
  note: Electronic resource.
  note: M.S. Texas A & M University 2003.
  note: Includes bibliographical references.
  note: Text (Thesis).
  subject:
    topic: nicotine tolerance
  subject:
    topic: corticosterone
  identifier: http://hdl.handle.net/1969.1/32
  record info:
    record content source: TXA
    record creation date: 040302
    record change date: 20151026051634.0
    record identifier: in00001803360