Optical biopsy for the early detection of skin cancer /
A new system was designed and assembled to non-invasively differentiate between pre-cancerous and benign human skin lesions. The system was calibrated and tested by measuring the optical properties, absorption coefficient and reduced scattering coefficient of phantom tissues and in-vitro chicken bre...
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
[Place of publication not identified] :
[publisher not identified] ;
2001.
|
| Subjects: | |
| Online Access: | http://proxy.library.tamu.edu/login?url=http://proquest.umi.com/pqdweb?did=726104571&sid=1&Fmt=2&clientId=2945&RQT=309&VName=PQD |
| Summary: | A new system was designed and assembled to non-invasively differentiate between pre-cancerous and benign human skin lesions. The system was calibrated and tested by measuring the optical properties, absorption coefficient and reduced scattering coefficient of phantom tissues and in-vitro chicken breast muscle. A broadband light source was coupled into a fiber optic probe. The pen-like probe was placed on the sample of interest, and the source fiber illuminated the media obliquely. A linear series of detection fibers in the probe that are normal to the sample were used to collect the diffuse reflectance. The skin lesions were classified by their melanocytic condition into two groups. Group 1 compared the cancerous basal and squamous cell carcinoma from the benign seborrheic and actinic keratosis. Group 2 compared the pre-cancerous dysplastic nevi from benign common, compound, and junctional nevi. The diffuse reflectance information gathered from pre-cancerous and benign skin tissues was analyzed for spatial and spectral features that could be correlated with the biopsy reports. Using feature analysis, the system achieved a classification of 100% for Group 1 and 95.2% for Group 2. Using these classifiers, the system was tested in a double blind study. The system achieved a classification of 92.9% for Group 1 and 100% for Group 2. This system could help physicians increase their assertion in the removal of dangerous skin conditions and in the reduction in the number of unnecessary biopsies. |
|---|---|
| Item Description: | Vita. "Major Subject: Biomedical Engineering". |
| Physical Description: | xii, 123 leaves : illustrations ; 28 cm. Issued also on microfiche from University Microfilm Inc. |
| Bibliography: | Includes bibliographical references (leaves 106-112). |