rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Identification and characterization of keratinocyte growth factor in the porcine uterus
  name:
    name part: Ka, Hak-Hyun
    name part: 1969-
    role:
      role term: creator
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: xx
    date issued: 2001
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    extent: ix, 151 leaves : illustrations ; 28 cm.
  abstract: The uterine growth, development and functional changes for the successful establishment and maintenance of pregnancy requires coordinated actions of various hormones and growth factors. Among many growth factors affected by steroid hormones, keratinocyte growth factor (KGF) is suggested to mediate progesterone action on uterine endometrial epithelial function in a paracrine manner in epithelial-mesenchymal interactions. Therefore, this research was conducted to determine: 1) effects of day and pregnancy status on KGF gene expression in the porcine uterine endometrium; 2) factors regulating KGF expression; and 3) function of KGF in the porcine uterus. The first study determined if KGF and its receptor (KGFR), were expressed in the porcine uterus as a potential paracrine system. The KGF gene was expressed solely by endometrial epithelia and was particularly abundant between Days 12 and 15 of the estrous cycle and pregnancy. KGFR was expressed in both endometrial epithelia and conceptus trophectoderm. KGF secretion into the lumen of the porcine uterus was detected on Day 12 of the estrous cycle and pregnancy. The second study determined factors affecting KGF gene expression in the uterus and the role of KGF on conceptus trophectoderm. Endometrial explants were cultured in the presence of estradiol-17β, catechol estrogens, or progesterone. Slot blot analyses revealed that estradiol-l7β increased KGF expression; catechol estrogens did not affect KGF expression; and progesterone slightly decreased KGF expression. KGF significantly increased proliferation of porcine trophectoderm cells as well as affected their differentiation. The third study determined effects of interleukin-lβ on KGF expression and KGF on endometrial epithelial cells in vivo and in vitro. Increasing doses of interleukin-lβ decreased KGF expression. In vivo administration of KGF did not affect proliferation and expression of several differentiation markers in the endometrial epithelia. Collectively, thes…
  note: by Hak-Hyun Ka.
  note: Vita.
  note: "Major Subject: Physiology of Reproduction".
  note: Issued also on microfiche from University Microfilm Inc.
  note: Ph. D. Texas A&M University 2001.
  note: Includes bibliographical references (leaves 120-150).
  subject:
    topic: Major physiology of reproduction
  identifier: 30-11741 UMI
  identifier: http://proxy.library.tamu.edu/login
  related item:
    location:
      url: http://proxy.library.tamu.edu/login
  record info:
    record content source: TXA
    record creation date: 020208
    record change date: 20190325102939.0
    record identifier: in00001653534