Progress toward synthesis of Hibarimicin B, a novel Src tyrosine kinase inhibitor /

The majority of all human neoplasms contain elevated tyrosine kinase activity, with unusually high levels of phosphotyrosine being a hallmark of tumor cells. Tyrosine kinase activity appears to be unregulated either by over expression of a proto-oncogenic tyrosine kinase or less frequently by mutat...

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