Progress toward synthesis of Hibarimicin B, a novel Src tyrosine kinase inhibitor /
The majority of all human neoplasms contain elevated tyrosine kinase activity, with unusually high levels of phosphotyrosine being a hallmark of tumor cells. Tyrosine kinase activity appears to be unregulated either by over expression of a proto-oncogenic tyrosine kinase or less frequently by mutat...
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| Format: | Thesis Book |
| Language: | English |
| Published: |
[Place of publication not identified] :
[publisher not identified] ;
2001.
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| Subjects: | |
| Online Access: | http://proxy.library.tamu.edu/login?url=http://proquest.umi.com/pqdweb?did=728909251&sid=1&Fmt=2&clientId=2945&RQT=309&VName=PQD |
| Summary: | The majority of all human neoplasms contain elevated tyrosine kinase activity, with unusually high levels of phosphotyrosine being a hallmark of tumor cells. Tyrosine kinase activity appears to be unregulated either by over expression of a proto-oncogenic tyrosine kinase or less frequently by mutation of the tyrosine kinase in a way which makes it constitutively activated. Chapter I of this dissertation describes the role of tyrosine kinase as well as some of the natural and synthetic tyrosine kinase inhibitors. Chapter II describes structure, biological activity and our first approach toward synthesis of a novel tyrosine kinase inhibitor, Hibarimicin B. This chapter will specifically describe our resolution route toward synthesis of AB and GH ring systems of hibarimicin's aglycon. Chapter III describes our second approach toward the ABCD/EFGH tetracylic core system of hibarimicins using the Hauser annulation protocol. |
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| Item Description: | Vita. "Major Subject: Chemistry". |
| Physical Description: | xvii, 158 leaves : illustrations ; 28 cm. Issued also on microfiche from University Microfilm Inc. |
| Bibliography: | Includes bibliographical references (leaves 79-84). |