rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Modulated expression of actin-cytoskeletal regulatory proteins and endothelial cell differentiation markers during capillary morphogenesis in three-dimensional collagen matrix
  name:
    name part: Salazar, Rene.
    role:
      role term: creator
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: xx
    date issued: 1999
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    extent: viii, 108 leaves : illustrations ; 28 cm.
  abstract: The formation of capillaries is critical during many physiologic and pathologic processes. The model of capillary morphogenesis in vitro uses human umbilical vein endothelial cells suspended within three-dimensional type I collagen gels. The cells undergo dramatic morphogenic changes to develop capillary lumens, tubes, and networks. Three proteins that regulate the actin cytoskeleton, gelsolin, vasodilator- stimulated phosphoprotein (VASP), and protein, change in expression during the formation of vascular structures. These changes are accompanied by changes in endothelial cell migratory behavior and cell morphology. The endothelial cell is observed to undergo a phenotypic change by examining changes in expression of endothelial marker molecules, adhesion molecules, growth factors, tyrosine kinase receptors, and extracellular matrix molecules. Using adenoviral constructs for VEGF121 and VEGF165, overexpression of these growth factors is observed to affect endothelial cell morphology during capillary morphogenesis. By inhibiting collagen synthesis, the formation of endothelial specific extracellular matrix during capillary morphogenesis is observed to be critical for the formation of vascular structures and maybe for endothelial cell survival in a three-dimensional matrix environment.
  note: by Rene Salazar.
  note: Vita.
  note: "Major Subject: Medical Sciences".
  note: Issued also on microfiche from University Microfilm Inc.
  note: Ph. D. Texas A&M University 1999.
  note: Includes bibliographical references (leaves 74-88).
  subject:
    topic: Major medical sciences
  identifier: 99-43566 UMI
  identifier: http://proxy.library.tamu.edu/login
  related item:
    location:
      url: http://proxy.library.tamu.edu/login
  record info:
    record content source: TXA
    record creation date: 000420
    record change date: 20190325093612.0
    record identifier: in00001540235