Administration of Salmonella enteritidis-immune lymphokines to neonatal turkeys and swine : effects on bacterial invasion and host innate immune functions /
We have previously reported an increased resistance to Salmonella enteritidis organ invasion in chicks and turkey poults injected prophylactically with S. enteriditis-immune lymphocytes. In the present studies, the efficacy of S. enteritidis-immune lymphocytes derived from a transformed chicken T ce...
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| Format: | Thesis Book |
| Language: | English |
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[Place of publication not identified] :
[publisher not identified] ;
1999.
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| Subjects: | |
| Online Access: | http://proxy.library.tamu.edu/login?url=http://proquest.umi.com/pqdweb?did=733668061&sid=1&Fmt=2&clientId=2945&RQT=309&VName=PQD |
| Summary: | We have previously reported an increased resistance to Salmonella enteritidis organ invasion in chicks and turkey poults injected prophylactically with S. enteriditis-immune lymphocytes. In the present studies, the efficacy of S. enteritidis-immune lymphocytes derived from a transformed chicken T cell line (VILK), to protect turkey poults and chicks against S. enteritidis organ invasion and the correlation between organ invasion and peripheral blood heterophilia was evaluated. In addition, the administration of VILK subcutaneously, orally, and intranasally was compared to intraperitoneal administration of VILK for protection from S. enteritidis organ invasion and functional activation of heterophils from day-old turkeys. Results from these experiments indicate that VILK does protect chicks and turkeys from S. enteritidis organ invasion, causes a peripheral blood heterophilia by four hours post-administration which correlates with the protection against S. enteritidis organ invasion, and activates the heterophils of day-old turkeys. In addition, these experiments show that VILK can be given by subcutaneous, oral, intranasal, or intraperitoneal administration with equal protection against S. enteritidis organ invasion, peripheral blood heterophilia and activation of heterophils from day-old turkeys. Experiments involving 132 weaned piglets were also conducted to evaluate the efficacy of a Salmonella enteritidis-immune lymphokine (PILK) derived from the T cells of S. enteritidis-immunized pigs to protect weaned piglets from Salmonella choleraesuis infection. PILK was found to protect weaned pigs from S. choleraesuis organ invasion cecal colonization and to enhance weight gain even in pigs with a S. choleraesuis infection. |
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| Item Description: | Vita. "Major Subject: Veterinary Microbiology". |
| Physical Description: | xi, 101 leaves : illustrations ; 28 cm. Issued also on microfiche from University Microfilm Inc. |
| Bibliography: | Includes bibliographical references (leaves 77-96). |