Studies of ODV-E56, an ODV envelope protein of Autographa Californica nucleopolyhedrovirus /
Baculovirus occlusion-derived virus (ODV) derives its envelope from membranes within the infected cell nucleus. An ODV envelope protein ODV-E56 (-E56) contains two hydrophobic sequences resembling the transmembrane domain of an integral membrane protein and it is detected in association with internu...
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| Format: | Thesis Book |
| Language: | English |
| Published: |
[Place of publication not identified] :
[publisher not identified] ;
1998.
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| Subjects: | |
| Online Access: | http://proxy.library.tamu.edu/login?url=http://proquest.umi.com/pqdweb?did=733050371&sid=1&Fmt=2&clientId=2945&RQT=309&VName=PQD |
| Summary: | Baculovirus occlusion-derived virus (ODV) derives its envelope from membranes within the infected cell nucleus. An ODV envelope protein ODV-E56 (-E56) contains two hydrophobic sequences resembling the transmembrane domain of an integral membrane protein and it is detected in association with internuclear membranes and ODV envelopes. Recombinant viruses containing mutations within -E56 were used to study regions of the amino acid sequence which functioned to locate -E56 to the ODV envelope. This study revealed that a hydrophobic domain (H2) is essential, yet not sufficient for protein localization into internuclear membranes. It was shown that -E56 interacted with a capsid protein p39. Abundant levels of -E56 inhibited ODV envelopment within the infected nuclei, suggesting a stoichiometric interaction between -E56 and an essential protein for ODV envelopment. |
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| Item Description: | Vita. "Major Subject: Biochemistry". |
| Physical Description: | xvi, 192 leaves : illustrations ; 28 cm. Issued also on microfiche from University Microfilm Inc. |
| Bibliography: | Includes bibliographical references (leaves 168-191). |