Apoptosis, reduced intracellular free calcium level and altered gene expression in the cerebellum of the leaner mutant mouse /

The homozygous leaner mouse exhibits the most severe ataxia among the approximately thirty currently known cerebellar mutant mice. Morphologic studies have revealed neuronal degeneration in the cerebellar cortex of the leaner mouse. The genetic etiology of the leaner mutation has recently been disco...

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