Developmental regulation of the cell cycle by the trol and ana genes of Drosophila melanogaster /
Development of multicellular organisms is complex and ofilm Inc. requires the coordination of numerous processes. For example, the production of cells that will make up various organs and tissues is an important process requiring strict control. During development, proliferative processes leading to...
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| Format: | Thesis Book |
| Language: | English |
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[Place of publication not identified] :
[publisher not identified] ;
1998.
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| Subjects: | |
| Online Access: | http://proxy.library.tamu.edu/login?url=http://proquest.umi.com/pqdweb?did=733050121&sid=1&Fmt=2&clientId=2945&RQT=309&VName=PQD |
| Summary: | Development of multicellular organisms is complex and ofilm Inc. requires the coordination of numerous processes. For example, the production of cells that will make up various organs and tissues is an important process requiring strict control. During development, proliferative processes leading to the production of these cells must be regulated in specific spatial and temporal patterns to ensure proper development. The temporal patterns to ensure proper development. temporal patterns to ensure proper development. The by the fact that terminal differentiation generally occurs once the cells have exited the proliferative state. The production of new populations of cells during development is dependent upon the division of specialized precursor cells called stem cells. Stem cells divide asymmetrically to produce two distinct progeny: one daughter cell has a restricted cell fate while the other maintains the stem cell identity. The progeny of stem cells are important contributors to the development of an organism since they have the ability to reproduce themselves with virtually unlimited capacity. Stem cells have been identified in numerous model systems indicating their basic biological importance. In this work, studies are presented that utilize the fruit fly, Drosophila melanogaster, as a model system to describe control of cell proliferation in neural stem cells called neuroblasts. This dissertation explores the regulation of neuroblasts by focusing on a genetic control element composed of the trol and ana genes of Drosophila and its link to particular elements of the cell cycle. The results strongly support regulation at the G1 to S transition and suggest a mechanism relating developmentally controlled genes to progression of the cell cycle. |
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| Item Description: | Vita. "Major Subject: Biochemistry". |
| Physical Description: | xi, 208 leaves : illustrations ; 28 cm. |
| Bibliography: | Includes bibliographical references (leaves 175-205 ). |