The use of mouse models to elucidate the genetic and environmental components of neural tube defects /
acid administered alone did not ameliorate the
| Main Author: | |
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| Format: | Thesis eBook |
| Language: | English |
| Published: |
[Place of publication not identified] :
[publisher not identified] ;
1998.
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| Subjects: | |
| Online Access: | Link to OAKTrust copy |
| Summary: | acid administered alone did not ameliorate the acid protected against arsenic-induced NTDS by and murine genomes. Furthermore, it is thought that and there is a high degree of homology between human animals. components contributing to their expression are confirm a role for [] and [] CT spinal NTDS and congenital anomalies affecting human infants defects, TGF-R. To otter clarify the impact of environmental factors on NTDS, Splotch mice were used extremely complex. Inbred mouse strains are highly folic acid induced lethality in arsenic treated folinic acid, were examined. Folic acid or folinic for the study of NTDS are the Splotch and curly-tail genetic factors contributing to spinal ' NTDS. The identify a new genetic factor contributing to these incidence of spontaneous NTDS in Splotch mice. Folic induced NTDS. Two forms of notate, folic acid and murine neuruation follows a pattern very similar to mutant mice. We used curly-tail mice to examine the Neural tub defects (NTDs) rank among the most common phics. neurulation by RT/aRNA amplification. Our observations nGNA levels of genes implicated in the curly-tail NTDS because their genetics are so well characterized phenotype, as well as other candidate genes for NTDS, regarded as animal models for studying the etiology of selective resolution of affected conceptuses, while that of humans. Two of the more popular murine models to examine the role of supplemental folate on the understood accuse the genetic and environmental were quantified over five timepoints during worldwide. Unfortunately, the: etiology is poorly |
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| Item Description: | "Major subject: Genetics". Vita. |
| Physical Description: | viii, 109 leaves : illustrations ; 28 cm. Also available online. |
| Bibliography: | Includes bibliographical references (leaves 88-108). |