rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Contact with dogs, canine distemper virus, and multiple sclerosis
  name:
    name part: Hutka, Marcus Dietrich.
    role:
      role term: creator
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: xx
    date issued: 1999
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    form: remote
    extent: x, 108 leaves : illustrations ; 28 cm.
  abstract: A case-control study of 28 multiple sclerosis (MS) patients and 23 other neurological disease (OND) controls matched on age, sex, and clinic location, was conducted to evaluate the possible effects of selected viral infections on the development of multiple sclerosis. All study subjects were members of the Scott and White Health Plan and residents of Belton, Bryan, College Station, or Temple, Texas. Participation entailed completing a 30-minute questionnaire and donating approximately 16 ml of venous blood. The questionnaire assessed exposure to dogs and other animals that can become infected with CDV. The questionnaire also obtained demographic information, residential, occupational, reproductive, and medical history, family history of disease, and multiple sclerosis data. Serum antibody titers to MV and CDV were measured using enzyme-linked immunosorbent assays (ELISA). Associations with serum antibodies to measles virus (MV) and canine distemper virus (CDV) were evaluated, while attempting to minimize the possibility of cross-reactivity. Two peptides were synthesized for each virus, using deduced amino acid sequences from segments of the hemagglutinin protein. The peptides were selected based on sequence heterogeneity between the two viruses and hydrophilicity. Elevated odds ratios were observed for several categories of self-reported exposures to dogs, however, 95% confidence intervals were wide, and included 1.0 in all instances. Mean absorbable values from ELISA did not differ significantly between cases and controls for any of the four peptides (t-test, p >0.05), nor did odds ratios show any significant associations between MS prevalence and serum absorbable values. Peptides that were previously reported as being specific to CDV exhibited highly correlated absorbable values with corresponding measles virus sequences (correlation coefficient >.95). Negative control antisera (rabbit anti-measles) for the distemper-origin peptides had higher absorbance values th…
  note: by Marcus Dietrich Hutka.
  note: "Major subject: Epidemiology".
  note: Vita.
  note: Also available online.
  note: Issued also on microfiche from Lange Micrographics.
  note: M.S. Texas A&M University 1999.
  note: Includes bibliographical references (leaves 51-57).
  subject:
    topic: Major epidemiology
  identifier: https://hdl.handle.net/1969.1/ETD-TAMU-1999-THESIS-H88
  related item:
    location:
      url: https://hdl.handle.net/1969.1/ETD-TAMU-1999-THESIS-H88
  record info:
    record content source: TXA
    record creation date: 991216
    record change date: 20220103134709.0
    record identifier: in00001506671