Iminosugars as glycosidase inhibitors : Nojirimycin and beyond /

Bibliographic Details
Other Authors:	Stütz, Arnold E.
Format:	Book
Language:	English
Published:	Weinheim ; New York : Wiley-VCH, [1999]
Subjects:	Glycosidases > Inhibitors. Imino compounds > Physiological effect. Enzyme inhibitors.

Table of Contents:

Sec. 1. The early days of monosaccharides containing nitrogen in the ring-- Sec. 2. Taxonomic distribution of iminosugars in plants and their biological activities-- Sec. 3. Glycosidase inhibition by basic sugar analogs and the transition state of enzymatic glycoside hydrolysis-- Sec. 4. Synthetic methods for the preparation of iminosugars-- Sec. 5. Iminosugars as powerful glycosidase inhibitors- synthetic approaches from aldonolactones-- Sec. 6. Isoiminosugars: glycosidase inhibitors with nitrogen at the anomeric position-- Sec. 7. Synthesis and biological activity of castanospermine and close analogs
Sec. 8. Some reflections on structure-activity relationships in glycosidase-inhibiting iminoalditols and iminosugars-- Sec. 9. Potent glycoside inhibitors: transition state mimics or simply fortuitous binders?-- Sec. 10. Iminoalditols as affinity ligands for the purification of glycosidases-- Sec. 11. Inhibitors of glycoprotein processing.