Mutational analysis of tissue-tissue interaction required for otic placode induction in zebrafish /
a source of otic inducing signals.
| Main Author: | |
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| Format: | Thesis eBook |
| Language: | English |
| Published: |
[Place of publication not identified] :
[publisher not identified] ;
1998.
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| Subjects: | |
| Online Access: | Link to OAKTrust copy |
| Summary: | a source of otic inducing signals. all mutants studied, expression of marker genes in Because the hindbrain mutant studied here is deficient contribution of each tissue has not been determined, deficient in cephalic mesoderm. In contrast, there deficient in prospective otic inducing tissues. The delayed in mesoderm deficient mutants. Our data development in mutants deficient in notochord Development of the vertebrate inner ear begins with aphics. for only a portion of the hindbrain, we cannot rule gastrulation. In contrast, the data suggest that the hindbrain differentiation. Similarly, induction of the identified. To address these issues, we analyzed otic indicating that otic induction was specifically induction of placates, as monitored by morphological mesoderm deficiency suggests that the hindbrain is not mutants that are deficient in cephalic mesoderm while nor have any genes controlling placate induction been notochord or hindbrain differentiation was normal. In notochord plays is not required for this process. notochord, and hindbrain. However, the relative observations, was delayed by 3h in mutants that are other regions of the neural plate was not delayed, otic inducing signals, including cephalic mesoderm, otic placate, as seen by upregulation of dlx-3 and out a role for that tissue in the regulation of otic pax-2 in pre-otic cells, was delayed by up to 313 in placate development. However, the observation that placate induction in zebrafish mutants that are signals required for otic induction during suggest that the cephalic mesoderm provides the first the induction of the otic placate. Several embryonic the timing of otic development in mutants deficient in this mutation did not potentiate defects caused by tissues have been implicated as potential sources of were no perturbations in the timing of otic |
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| Item Description: | "Major subject: Biology". Vita. |
| Physical Description: | vi, 28 leaves : illustrations ; 28 cm. Also available online. |
| Bibliography: | Includes bibliographical references: 23-27. |