http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
TNF Alpha concentration in tumored and non-tumored Sinclair swine
TNF concentration in tumored and non-tumored Sinclair swine
viii, 55 leaves : illustrations ; 28 cm.
The infiltration of pigment-laden macrophages (PLM) in Sinclair swine cutaneous melanoma during the time frame in which histopathological evidence of tumor regression is observed suggests that they may play a role in this event. Tumor necrosis factor alpha (TNF[alpha]c) is a major cytotoxic secretagogue of activated macrophages. This study analyzed the circulating and intratumoral levels of TNF[alpha] in melanoma-positive and melanoma-free Sinclair swine over the first 100 days of age. TNF[alpha] concentrations were measured by porcine-specific TNF[alpha] ELISA. The mean serum TNF[alpha] concentration of all tumored pig samples combined (23.2 pg/n-d) was significantly higher than non-tumored pigs (15.97 pg/ml). However, comparisons of age groups between tumored and non-tumored pigs showed no significant differences. Comparisons of different ages within a tumor status group showed significant changes in serum TNF[alpha] concentrations. Intratumoral concentrations of TNF[alpha](X showed a significant decrease from 260.9 pg/ml to 40.4 pg/n-A over the first 100 days of age. These studies indicate that differences in TNF[alpha] serum and intratumoral concentrations occur in Sinclair swine and these may be correlated with age and tumor status.
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Includes bibliographical references: 42-52.