rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    non sort: The
    title: Design And Synthesis Of Nuclear Localization Signal (NLS) Mimics
  name:
    name part: Ho, Thai Huu.
    role:
      role term: creator
  name:
    name part: Ho, Thai Huu.
    role:
      role term: creator
  name:
    name part: Standaert, Robert F.
    role:
      role term: degree supervisor.
  name:
    name part: Texas A & M University
    name part: University Undergraduate Research Fellow Program.
  type of resource: text
  genre: Undergraduate thesis
  origin info:
    place:
      place term: txu
    date issued: 1998
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    extent: 1 online resource (31 pages).
  abstract: Nuclear import of proteins is a carefully controlled process that is critical for cellular function and regulation. A protein is marked for nuclear entry by a nuclear localization signal (NLS), a peptide motif, which typically consists of one or two small clusters rich in basic amino acids (lysine or arginine). Transport occurs through pores that span the nuclear envelope by a receptor mediated, energy-dependent process. The goal of this study is to synthesize mimics of the NLS from aminoalkylated dihydroxybenzene fragments joined with linkers of various length, rigidity, and directional constraint. The project is part of a larger effort to understand the molecular recognition in nuclear protein import; its emphasis is to study the role of charge placement, orientation, and linker features in NLS recognition.
  abstract: Modeled after the NLS of the HIV-1 matrix protein, the proposed molecules can mimic the side chain placement of the NLS template. Candidates are evaluated for inhibition in an in vitro nuclear import assay. Inhibition was not observed for all the candidates despite the presence of positively charged clusters. The results suggest inhibition is not solely based on the presence of positive charge and confirms the hypothesis that other factors, such as orientation, are important.
  target audience: specialized
  note: "Major Subject: Biochemistry/Chemistry".
  note: Digitized from print version held at Pickle Center High Density Storage, barcode 24829659
  note: Fellows Thesis Texas A&M University 1998.
  note: Includes bibliographical references: leaves 28-29.
  note: HDR
  subject:
    topic: Major biochemistry/chemistry
  subject:
    topic: aminoalkylated dihydroxybenzene
  identifier: http://hdl.handle.net/1969.1/ETD-TAMU-1998-Fellows-Thesis-H63
  identifier: https://hdl.handle.net/1969.1/ETD-TAMU-1998-Fellows-Thesis-H63
  related item:
    location:
      url: http://hdl.handle.net/1969.1/ETD-TAMU-1998-Fellows-Thesis-H63
  record info:
    record content source: TXA
    record creation date: 231116
    record change date: 20151021053421.0
    record identifier: in00001465164