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Uncoupling at the GABA(A) receptor with chronic ethanol in the rat medial septum/diagonal band (MS/DB) /

(0. I uM) and GABA (0. I uM) in the ethanol treated cells.

Bibliographic Details
Main Author: Wallace, Kathleen Allison, 1969-
Format: Thesis eBook
Language:English
Published: [Place of publication not identified] : [publisher not identified] ; 1997.
Subjects:
Major medical sciences.
Online Access:Link to OAKTrust copy
Description
Summary:(0. I uM) and GABA (0. I uM) in the ethanol treated cells.
a neurosteroid is uncoupled by chronic ethanol treatment
adaptive changes by the CNS may occur. Adaptation could
agonist or allosteric modulator. Varying results have been
allopregnanolone (1.0 [uM) did show potentiation of the 3 uM
allosteric mechanisms. However, the higher (1 [uM
an allosteric modulator at the receptor without a change in
and 1. 0 liM), loreclezole (10 [uM), or allopregnanolone (0.
appear that chronic ethanol uncoupled potentiation of
capable of directly activating the GABAAreceptor, did show
changes in the function of neurotransmitter systems which
chronic drug treatment. The goal of this project was to
concentration of allopregnanolone, which is thought to be
contrast, an increased potentiation was seen with midazolam
dependence with ethanol are allosteric modulators at the
dependence. Chronic ethanol was not found to induce an
depressants. These agents which show cross-tolerance and
determine-tine whether allosteric potentiation of
ethanol; this finding is consistent with an adaptive change
Functional tolerance to ethanol and physical dependence are
GABA response in the chronically ethanol treated cells. In
GABAAreceptor. Uncoupling is the decrease in the activity of
GABAAreceptors by a benzodiazepine, a novel anticonvulsant or
I uM) to 3 uM GABA. However, the higher concentration of
in GABAAreceptor function.
Increasing evidence suggests that the y-aminobutyric acid
loreciezole or 0. I [uM allopregnanolone acting by general
No potentiation was seen of 30 liM GABA response with any of
obtained when looking at uncoupling at the GABAAreceptor with
occur by downregulation of GABAAreceptor number or uncoupling
of the GABAAreceptor sensitivity to ethanol and related CNS
receptor number after prolonged exposure to either the
resist the initial intoxicating actions of ethanol.
the allosteric modulators tested. Therefore, it does not
thought to involve central nervous system (CNS) adaptive
typeA(GABA,) receptor is one target of ethanol where such
uncoupling of potentiation with cells chronically exposed to
uncoupling of the potentiation seen with rnidazolam (0. I
which may contribute to functional tolerance and physical
Item Description:"Major subject: Medical Sciences".
In title, subscripts are used.
Vita.
Physical Description:xii, 71 leaves : illustrations ; 28 cm.
Also available online.
Issued also on microfiche from Lange Micrographics.
Bibliography:Includes bibliographical references: 63-70.