Effects of chronic cadmium exposure on the conditioned reinforcing properties of morphine and fentanyl in rats /
(CPP). In CPP a drug is repeatedly paired with a neutral
| Main Author: | |
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| Format: | Thesis eBook |
| Language: | English |
| Published: |
[Place of publication not identified] :
[publisher not identified] ;
1997.
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| Subjects: | |
| Online Access: | Link to OAKTrust copy |
| Summary: | (CPP). In CPP a drug is repeatedly paired with a neutral 0.04 mg/kg)were systemically administered (sc) and rats abuse. The experiments presented examined the effects of all drugs were paired with the least-preferred side as and fentanyl using the conditioned place preference paradigm cadmium on the conditioned reinforcing properties of morphine cadmium-exposed animals showed preference at 5 jig only. cadmium-exposed rats received 0, 0.6, 1.25, 2.5. or 5 mg/kg cadmium. CPP was conducted in a 2-chamber apparatus in which Chronic exposure to the toxicant cadmium has been shown to CNS. An attenuation by cadmium again was observed, as conditioned reinforcing properties of the opiates. control animals showed a place preference at 2 and 5 @g and days. Control animals showed a preference for the drug- determine whether the results seen in Experiment 1 were due determined on a pre-test. In Experiment 1. control and environment. In these experiments adult male rats were Experiment 2. rats were implanted with cannulae into the exposed ad libitum for 40 days to 100 ppm cadmium chloride exposed rats showed a preference at 5 mg/kg only. In In Experiment 3, increasing doses of the selective g- lateral ventricles and or 5 morphine sulfate more time in the drugpaired rather than a non-drug-paired morphine sulfate (ip) for 4 days, and vehicle only for 4 opioidreceptor agonist fentanyl (0, 0.0004, 0.004, and paired side at 1.25, 2.5. and 5 mg/kg while the cadmium- point to an attenuation rather than a suppression of the preference at 0.0004, 0.004, and 0.04 mg/kg. These results preference only at 0.04 mg/kg, control animals showed produce an attenuation in behavior properties of drugs of stimulus. When given free-choice access, the animal spends tested for CPP. While cadmium animals showed place through their diet, or an identical diet with no added to an antagonsim by cadmium in the periphery rather than the was administered intracerebroventricularly (icv) to |
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| Item Description: | "Major subject: Psychology". Vita. |
| Physical Description: | viii, 60 leaves : illustrations ; 28 cm. Also available online. Issued also on microfiche from Lange Micrographics. |
| Bibliography: | Includes bibliographical references: pages 48-58. |