rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Butyrate and the colonocyte
    sub title: effect on cellular events and role in protection against colon cancer
  name:
    name part: Zoran, Debra L.
    role:
      role term: creator
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: xx
    date issued: 1997
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    extent: xiv, 227 leaves : illustrations ; 28 cm.
  abstract: Colon cancer is a common and deadly human disease that is
  abstract: strongly linked to dietary and environmental factors, both in
  abstract: initiation and progression of tumorigenesis. Dietary fibers
  abstract: and one of their byproducts, butyrate, are alternately linked
  abstract: to prevention or promotion of tumor development. Poorly
  abstract: fermented dietary fibers, such as wheat bran or cellulose,
  abstract: are believed to be protective. Conversely, highly fermented
  abstract: fibers, such as pectin or oat bran, may not be protective.
  abstract: Butyrate production by fiber fermentation may be an important
  abstract: part of its protective effects, because of the apparently
  abstract: different effects butyrate has on normal versus transformed
  abstract: colonocytes. Thus, this investigation was undertaken to
  abstract: study the effects of two different fibers, wheat bran and oat
  abstract: bran, and their fermentation by-product, butyrate on luminal
  abstract: pH, intracellular pH, cell cycle indices and apoptosis in
  abstract: freshly isolated colonocytes and on the development of tumors
  abstract: in a rodent model of colon cancer. The results of this
  abstract: investigation have addressed several major issues relating to
  abstract: colon cancer development and dietary fiber supplementation.
  abstract: Rats consuming oat bran diets produced the largest
  abstract: concentrations of butyrate, yet developed significantly more
  abstract: and larger tumors than rats consuming wheat bran diets. Oat
  abstract: bran rats also had lower luminal pH values, which was
  abstract: predicted to be protective, but was not correlated with
  abstract: decreased tumor incidence. Intracellular pH was more
  abstract: alkaline in carcinogen injected rats fed wheat bran diets,
  abstract: while in saline rats there was no difference in intracellular
  abstract: pH between diets. Thus, reduction of intracellular pH,
  abstract: presumably by the presence of increased SCFA was not
  abstract: protective. Finally, neither diet nor carcinogen treatment
  abstract: had a significant effect on cell cycle position (e.g.
  abstract: percentage of S phase cells) or apoptosis. In conclusion,
  abstract: these data show that while diets containing wheat bran fiber
  abstract: bran fiber are not, it is not luminal butyrate concentrations
  abstract: that are of primary importance to this effect.
  note: by Debra L. Zoran.
  note: Vita.
  note: "Major Subject: Nutrition".
  note: Issued also on microfiche from University Microfilms Inc.
  note: Includes bibliographical references: pages 149-180.
  note: Ph. D. Texas A&M University 1997.
  subject:
    topic: major nutrition
  identifier: 98-15872 UMI
  identifier: http://proxy.library.tamu.edu/login
  related item:
    location:
      url: http://proxy.library.tamu.edu/login
  record info:
    record content source: TXA
    record creation date: 980717
    record change date: 20190325093353.0
    record identifier: in00001431026