| Tag |
First Indicator |
Second Indicator |
Subfields |
| LEADER |
00000ctm a22000005a 4500 |
| 001 |
in00001429421 |
| 005 |
20190325093512.0 |
| 008 |
980630s1997 xx a b 000 0 eng d |
| 035 |
|
|
|a (OCoLC)39372455
|
| 035 |
|
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|9 AHR1090AM
|
| 037 |
|
|
|a 98-15718
|b UMI
|
| 040 |
|
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|a TXA
|c TXA
|d UtOrBLW
|
| 049 |
|
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|a TXAM
|a TXAR
|
| 099 |
|
|
|a 1997
|a Dissertation
|a C653
|
| 100 |
1 |
|
|a Collie, Shanna Lee.
|
| 245 |
1 |
0 |
|a Risk assessment of complex mixtures of polycyclic aromatic hydrocarbons (PAHs) at superfund sites /
|c by Shanna Lee Collie.
|
| 264 |
|
1 |
|a [Place of publication not identified] :
|b [publisher not identified] ;
|c 1997.
|
| 300 |
|
|
|a xiv, 181 leaves :
|b illustrations ;
|c 28 cm.
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a unmediated
|b n
|2 rdamedia
|
| 338 |
|
|
|a volume
|b nc
|2 rdacarrier
|
| 504 |
|
|
|a Includes bibliographical references: pages 131-143.
|
| 500 |
|
|
|a Vita.
|
| 502 |
|
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|b Ph. D.
|c Texas A&M University
|d 1997.
|
| 500 |
|
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|a "Major Subject: Toxicology".
|
| 530 |
|
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|a Issued also on microfiche from University Microfilms Inc.
|
| 520 |
|
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|a This research was designed to determine whether a component-
|
| 520 |
|
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|a based chemical characterization can effectively predict the
|
| 520 |
|
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|a same mutagenic (and ultimately, carcinogenic) potential of a
|
| 520 |
|
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|a whole-mixture extract as detectable in direct in vitro
|
| 520 |
|
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|a testing. In so doing, soil and waste samples were collected
|
| 520 |
|
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|a at "Superfund" sites planning or undergoing remediation for
|
| 520 |
|
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|a extraction. Extracts were tested qualitatively and
|
| 520 |
|
|
|a quantitatively for mutagenicity using the
|
| 520 |
|
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|a Salmonella/microsome and/or the E. coli prophage induction
|
| 520 |
|
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|a assays. Quantitative and qualitative chemical analysis
|
| 520 |
|
|
|a formed the basis for the cancer risk assessment, which was
|
| 520 |
|
|
|a intended to provide a component-based estimate of the
|
| 520 |
|
|
|a carcinogenic potential of the mixture extracts based on an
|
| 520 |
|
|
|a assumption of additivity. The chemical component-based risk
|
| 520 |
|
|
|a assessment includes a limited number of specific carcinogenic
|
| 520 |
|
|
|a components, whereas the results of the in vitro genotoxicity
|
| 520 |
|
|
|a assays were shown to reflect the response of the whole
|
| 520 |
|
|
|a complex mixture extract. No clear-cut correlations held for
|
| 520 |
|
|
|a all four sites described when either specific or weighted
|
| 520 |
|
|
|a mutagenic activity values were compared with estimated
|
| 520 |
|
|
|a lifetime cancer risk. The striking absence of mutagenicity
|
| 520 |
|
|
|a in the Site 4 sample that carried a plausible upper bound
|
| 520 |
|
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|a excess cancer incidence of 238 per million exposed population
|
| 520 |
|
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|a is one example of how biological testing (especially a single
|
| 520 |
|
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|a endpoint) alone may not be a reliable measure of risk. At
|
| 520 |
|
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|a the same time, results from testing of Site 1 samples
|
| 520 |
|
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|a indicated that although treatment and dilution of highly
|
| 520 |
|
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|a contaminated soils greatly decreased the resultant cancer
|
| 520 |
|
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|a risk to below target levels, a battery of genotoxicity assays
|
| 520 |
|
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|a could not confirm the risk assessment findings. Departures
|
| 520 |
|
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|a between direct whole-mixture in vitro mutagenicity testing
|
| 520 |
|
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|a and carcinogenic potential based on additive, component-based
|
| 520 |
|
|
|a calculations were investigated. This research thus
|
| 520 |
|
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|a determined that the component-based approach to cancer risk
|
| 520 |
|
|
|a assessment of complex mixtures described here did not concur
|
| 520 |
|
|
|a with the direct in vitro whole-mixture approach to assessing
|
| 520 |
|
|
|a mutagenic (and ultimately, carcinogenic) potential.
|
| 650 |
|
4 |
|a Major toxicology.
|
| 856 |
4 |
1 |
|u http://proxy.library.tamu.edu/login?url=http://proquest.umi.com/pqdweb?did=736824201&sid=1&Fmt=2&clientId=2945&RQT=309&VName=PQD
|t 0
|
| 948 |
|
|
|a c:en
|
| 999 |
|
|
|a MARS
|
| 999 |
f |
f |
|s 49b06feb-f41d-3cc9-8088-dd44198b2b67
|i 4c5a1aaa-6d11-394c-8c43-4d6964a0c3e9
|t 0
|
| 952 |
f |
f |
|p noncirc
|a Texas A&M University
|b College Station
|c Cushing Memorial Library & Archives
|s cush tdrm
|d Cushing: Theses & Dissertations Microforms (Does not check out)
|t 0
|e 1997 Dissertation C653
|h Other scheme
|i unmediated -- volume
|
| 952 |
f |
f |
|a Texas A&M University
|b College Station
|c Electronic Resources
|s www_evans
|d Available Online
|t 0
|e 1997 Dissertation C653
|h Other scheme
|
| 998 |
f |
f |
|a 1997 Dissertation C653
|t 0
|l Cushing: Theses & Dissertations Microforms (Does not check out)
|
| 998 |
f |
f |
|a 1997 Dissertation C653
|t 0
|l Available Online
|