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Glucagon-like peptide-1 : a feeding-inhibitory peptide within the hypothalamic paraventricular nucleus /

Glucagon-like peptide-1 (7-36) amide (GLP-1), a glucose-

Bibliographic Details
Main Author: McMahon, Lance Richard
Format: Thesis Book
Language:English
Published: [Place of publication not identified] : [publisher not identified] ; 1997.
Subjects:
Major psychology.
Online Access:http://proxy.library.tamu.edu/login?url=http://proquest.umi.com/pqdweb?did=736824611&sid=1&Fmt=2&clientId=2945&RQT=309&VName=PQD
Description
Summary:Glucagon-like peptide-1 (7-36) amide (GLP-1), a glucose-
dependent insulin secretagogue, is released by the distal
ileum in response to food entering the gut. Infusion of GLP-
1 into the brain ventricles dose-dependently inhibits
feeding. The intent of the present experiments was to
determine whether infusion of GLP-1 into the hypothalamic
paraventricular nucleus (PVN) would suppress feeding through
the induction of satiety, and to determine whether the PVN
serves a primary role in the feeding-inhibitory action of
central GLP-1. Experiment 1 revealed that PVN infusion of
100 and 200 ng GLP-1 dose-dependently reduced consumption of a
palatable liquid diet. Experiment 2 demonstrated that PVN
infusion of GLP-1 (100 and 200 ng) did not induce malaise as
assessed by a conditioned taste aversion paradigm, and
Experiment 3 demonstrated that PVN infusion of GLP-1 (100 and
200 ng) did not significantly alter locomotion. Experiment 4
revealed that PVN infusion of 100 and 200 ng GLP-1
significantly reduced pellet chow and water intake, but that
infusion of GLP-1 (100 and 200 ng) into brain sites ventral
and/or lateral to the PVN did not suppress feeding or
drinking. Experiment 5 demonstrated that PVN infusion of
GLP-1 (100 and 200 ng) reduced feeding without disrupting the
behavioral satiety sequence, suggesting that exogenous GLP-1
within the PVN promotes satiety. Finally, Experiment 6
revealed that the anorexia induced by lateral ventricular
infusion of GLP-1 was abolished by bilateral electrolytic
lesion of the PVN. These results suggest that the PVN
mediates the anorexia induced by ventricular infusion of GLP-
1, and that exogenous GLP-1 within the PVN promotes satiety.
Item Description:Vita.
"Major Subject: Psychology".
In title, numerals are used.
Physical Description:ix, 155 leaves : illustrations ; 28 cm.
Issued also on microfiche from University Microfilms Inc.
Bibliography:Includes bibliographical references: pages 126-154.