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First Indicator |
Second Indicator |
Subfields |
| LEADER |
00000ctm a22000005a 4500 |
| 001 |
in00001418821 |
| 005 |
20190325093506.0 |
| 008 |
980415s1997 xx a b 000 0 eng d |
| 035 |
|
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|a (OCoLC)38953055
|
| 035 |
|
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|9 AHP4127AM
|
| 037 |
|
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|a 98-00830
|b UMI
|
| 040 |
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|a TXA
|c TXA
|d UtOrBLW
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| 049 |
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|a TXAM
|a TXAR
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| 099 |
|
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|a 1997
|a Dissertation
|a Z422
|
| 100 |
1 |
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|a Zenger, Elizabeth,
|d 1963-
|
| 245 |
1 |
0 |
|a Characterization of astroglial dysfunction following feline immunodeficiency viral infection /
|c by Elizabeth Zenger.
|
| 264 |
|
1 |
|a [Place of publication not identified] :
|b [publisher not identified] ;
|c 1997.
|
| 300 |
|
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|a xiii, 101 leaves :
|b illustrations ;
|c 28 cm.
|
| 336 |
|
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|a text
|b txt
|2 rdacontent
|
| 337 |
|
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|a unmediated
|b n
|2 rdamedia
|
| 338 |
|
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|a volume
|b nc
|2 rdacarrier
|
| 504 |
|
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|a Includes bibliographical references: pages 88-100.
|
| 500 |
|
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|a Vita.
|
| 502 |
|
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|b Ph. D.
|c Texas A&M University
|d 1997.
|
| 500 |
|
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|a "Major Subject: Veterinary Anatomy".
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| 530 |
|
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|a Issued also on microfiche from University Microfilms Inc.
|
| 520 |
|
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|a Lentiviruses including HIV and FIV are able to efficiently
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| 520 |
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|a enter the central nervous system (CNS) and cause primary
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| 520 |
|
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|a neurological disease that is not attributable to
|
| 520 |
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|a opportunistic infections or systemic disease. Although a
|
| 520 |
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|a substantial degree of neuronal loss can occur in the cortex
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| 520 |
|
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|a of HIV- or FIV-infected patients, most studies agree that
|
| 520 |
|
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|a neurons are not infected and indirect mechanisms of
|
| 520 |
|
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|a neurotoxicity are postulated. Target cells for FIV in the
|
| 520 |
|
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|a brain are similar to those observed in HIV infection, i.e.,
|
| 520 |
|
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|a both viruses infecting astrocytes and microglia. The
|
| 520 |
|
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|a importance of asttoglia in the maintenance of CNS functions
|
| 520 |
|
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|a suggests that virally induced changes in infected astroglia
|
| 520 |
|
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|a may be essential in the progression of lentivirus-associated
|
| 520 |
|
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|a neurologic disease. This dissertation describes a model
|
| 520 |
|
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|a system that was developed to study the effects of two
|
| 520 |
|
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|a divergent FIV strains on astroglia in vitro. Effects of
|
| 520 |
|
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|a astroglial infection by the nonneurovirulent Petaluma strain
|
| 520 |
|
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|a of FIV (FIV-Pet) and the highly neurovirulent Maryland Strain
|
| 520 |
|
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|a of FIV (FIV-MD) were compared. Astroglia were readily
|
| 520 |
|
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|a infected by FIV-Pet and this infection was productive with
|
| 520 |
|
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|a high titers of virus being produced by infected cells within
|
| 520 |
|
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|a several days of infection. In contrast, astroglial infection
|
| 520 |
|
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|a by FIV-MD could only be accomplished by lymphocyte
|
| 520 |
|
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|a facilitation and was nonproductive. Results of assays
|
| 520 |
|
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|a examining the cytotoxic potential of these viruses suggest
|
| 520 |
|
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|a that FIV-Pet infection of astroglia seems to be much more
|
| 520 |
|
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|a cytotoxic than FIV-MD. Further, FIV-Pet causes a much more
|
| 520 |
|
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|a profound decrease in astroglial glutamate uptake than does
|
| 520 |
|
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|a FIV-MD. The results of this study suggest that the
|
| 520 |
|
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|a differences in neurovirulence observed in vivo may relate to
|
| 520 |
|
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|a specific differences in the mechanism of astroghal infection,
|
| 520 |
|
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|a viral expression, tendency to cause cytotoxicity, and ability
|
| 520 |
|
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|a to cause alteration of astroglial function. Although these
|
| 520 |
|
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|a in vitro results may seem contradictory to that expected
|
| 520 |
|
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|a initially, these results may actually correlate well with the
|
| 520 |
|
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|a paradoxical nature of CNS lesions and clinical neurological
|
| 520 |
|
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|a symptomatology associated with these viral strains.
|
| 650 |
|
4 |
|a Major veterinary anatomy.
|
| 856 |
4 |
1 |
|u http://proxy.library.tamu.edu/login?url=http://proquest.umi.com/pqdweb?did=736580661&sid=1&Fmt=2&clientId=2945&RQT=309&VName=PQD
|t 0
|
| 948 |
|
|
|a c:en:en
|
| 999 |
|
|
|a MARS
|
| 999 |
f |
f |
|s 2b51d53e-551e-35a4-8961-8f3a10d2acec
|i 777dd5cd-6450-32ac-a1d7-43a02b512162
|t 0
|
| 952 |
f |
f |
|p noncirc
|a Texas A&M University
|b College Station
|c Cushing Memorial Library & Archives
|s cush tdrm
|d Cushing: Theses & Dissertations Microforms (Does not check out)
|t 0
|e 1997 Dissertation Z422
|h Other scheme
|i unmediated -- volume
|
| 952 |
f |
f |
|a Texas A&M University
|b College Station
|c Electronic Resources
|s www_evans
|d Available Online
|t 0
|e 1997 Dissertation Z422
|h Other scheme
|
| 998 |
f |
f |
|a 1997 Dissertation Z422
|t 0
|l Available Online
|
| 998 |
f |
f |
|a 1997 Dissertation Z422
|t 0
|l Cushing: Theses & Dissertations Microforms (Does not check out)
|