http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Structure determination -- Amino acid analysis -- Sequence determination -- End group determination -- Sequential degradation -- Sequence determination with the help of mass spectra -- Fragmentation of peptides -- Secondary and tertiary structure -- Architectural features in peptides -- Methods for the analysis of conformation of peptides -- Prediction of conformation in peptides -- Peptide synthesis -- Formation of the peptide bond -- Acid chloride method -- Acid azide method -- Anhydrides -- Active esters -- Coupling reagents -- Enzyme-catalyzed bond formation -- Non-conventional methods of peptide bond formation -- Protection of functional groups -- Blocking of α-amino groups -- Blocking of side chain amino groups -- Protection of the carboxyl group -- Protection of hydroxyl groups -- Blocking of the sulfhydryl group -- Masking the thioether in methionine -- Protection of the guanidine function in the arginine side chain -- Masking the imidazole in histidine -- Indole protection -- Carboxamide blocking groups.
(cont) Undesired reactions during synthesis -- Base-catalyzed ring closure -- Acid-catalyzed ring closure -- Acyl migration -- Alkylation -- Friedel-Crafts reaction -- Saturation of aromatic nuclei -- Reductive cleavage of the peptide chain -- Oxidative decomposition of the indole in tryptophan -- Side reactions caused by steric hindrance -- Prevention and suppression of side reactions -- Racemization -- Mechanism of racemization -- Detection of racemization -- Racemization studies in model systems -- Prevention of racemization -- Design of schemes for peptide synthesis -- Segment condensation -- Stepwise chain-lengthening starting with the N-terminal residue -- Stepwise chain-lengthening starting with the C-terminal residue -- Tactical consideration -- Synthesis of special target peptides -- Solid phase peptide synthesis -- Insoluble polymeric support and the bond linking the peptide to the resin -- Removal of temporary blocking groups -- Coupling: acylation of the resin-bound amine-component -- Separation of the completed peptide chain from the polymeric support and final deprotection.
(cont) Some problems encountered in solid phase peptide synthesis -- Methods of facilitation -- Chains attached to a soluble polymer -- Picolyl ester method -- Rapid synthesis -- Synthesis in situ -- Simultaneous synthesis of peptide analogs -- Insoluble reagents -- Analysis and characterization of synthetic peptides -- Homogeneity tests -- Amino acid analysis and sequence determination -- Elemental analysis -- Measurement of optical activity -- Infrared and ultraviolet absorption spectra -- Nuclear magnetic resonance spectra -- Molecular-weight determination.
Includes bibliographical references and index.