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| LEADER |
00000ctm a22000005a 4500 |
| 001 |
in00001384413 |
| 005 |
20220103134717.0 |
| 007 |
cr unu a |
| 008 |
971006s1997 xx a b 000 0 eng d |
| 035 |
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|9 AHL2134AM
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| 035 |
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|a (OCoLC)37741095
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| 040 |
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|a TXA
|c TXA
|d UtOrBLW
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| 049 |
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|a TXAM
|a TXAR
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| 099 |
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|a 1997
|a Thesis
|a S37
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| 100 |
1 |
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|a Schrope, Katherine Eillene.
|
| 245 |
1 |
0 |
|a Regulation of insulin-like growth factor binding protein-4 in Ah responsive and Ah nonresponsive human breast cancer cells by 17 B-estradiol and 2,3,7,8 tetrachlorodibenzo-p-dioxin /
|c by Katherine Eillene Schrope.
|
| 246 |
3 |
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|a Regulation of insulin-like growth factor binding protein-four in Ah responsive and Ah nonresponsive human breast cancer cells by seventeen Beta-estradiol and two, three, seven, eight tetrachlorodibenzo-p-dioxin
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| 264 |
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1 |
|a [Place of publication not identified] :
|b [publisher not identified] ;
|c 1997.
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| 300 |
|
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|a xii, 113 leaves :
|b illustrations ;
|c 28 cm.
|
| 336 |
|
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|a text
|b txt
|2 rdacontent
|
| 337 |
|
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|a computer
|b c
|2 rdamedia
|
| 338 |
|
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|a online resource
|b cr
|2 rdacarrier
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| 500 |
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|a "Major subject: Biochemistry".
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| 500 |
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|a In title, Greek symbol Beta and numerals are used.
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| 500 |
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|a Vita.
|
| 502 |
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|b M.S.
|c Texas A&M University
|d 1997.
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| 504 |
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|a Includes bibliographical references.
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| 520 |
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|a (Ah) nonresponsive cells (BaP MCF-7 and T47D5 cells) were
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| 520 |
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|a (E2) induced IGFBP-4 protein secretion and MRNA expression
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| 520 |
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|a affected 24 hours after treatment. Aryl-hydrocarbon receptor
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| 520 |
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|a and these effects were decreased after co-treatment with 10
|
| 520 |
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|a and wild-type cells, with the exception of IGFBP-5. IGFBP-4
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| 520 |
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|a caused a decrease in constitutive secretion of IGFBP-4,
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| 520 |
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|a cells were not significantly different. These data support
|
| 520 |
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|a cells. In contrast, when detected by immunoblot analysis
|
| 520 |
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|a detected IGFBP-4 at 80 and 14-fold lower levels in the BaP
|
| 520 |
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|a expression. In human breast cancer cells, 17 O-estradiol
|
| 520 |
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|a factor binding protein-4 (IGFBP-4) protein secretion and MRNA
|
| 520 |
|
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|a however, the constitutive IGFBP-4 MRNA levels were not
|
| 520 |
|
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|a IGFBPs were secreted at similar levels in Ali nonresponsive
|
| 520 |
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|a MCF-7 and T47D5 cells, respectively compared to wild-type
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| 520 |
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|a MRNA levels expressed in T47D, T47D5, MCF-7 and BaP MCF-7
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| 520 |
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|a nM TCDD. In MCF-7 human breast cancer cells, 10 nM TCDD
|
| 520 |
|
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|a regulation of IGFBP-4 by TCDD. Western ligand blot analysis
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| 520 |
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|a tetrachlorodibenzo-p-dioxin (TCDD) on insulin-like growth
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| 520 |
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|a the hypothesis that IGFBPs in the BaP MCF-7 and T47D5.
|
| 520 |
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|a This study focused on the effects of 2,3,7,8-
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| 520 |
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|a utilized to investigate the role of the Ah-receptor in the
|
| 530 |
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|a Also available online.
|
| 530 |
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|a Issued also on microfiche from Lange Micrographics.
|
| 650 |
|
4 |
|a Major biochemistry.
|
| 856 |
4 |
1 |
|u https://hdl.handle.net/1969.1/ETD-TAMU-1997-THESIS-S37
|z Link to OAKTrust copy
|t 0
|
| 999 |
|
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|a MARS
|
| 999 |
f |
f |
|s dbd65732-84ad-3e49-ba3e-2f44f5e12465
|i dae3e9e8-00ef-3268-938d-e05da52851ab
|t 0
|
| 952 |
f |
f |
|p noncirc
|a Texas A&M University
|b College Station
|c Cushing Memorial Library & Archives
|s cush tdrm
|d Cushing: Theses & Dissertations Microforms (Does not check out)
|t 0
|e 1997 Thesis S37
|h Other scheme
|i computer -- online resource
|
| 952 |
f |
f |
|a Texas A&M University
|b College Station
|c Electronic Resources
|s www_evans
|d Available Online
|t 0
|e 1997 Thesis S37
|h Other scheme
|
| 998 |
f |
f |
|a 1997 Thesis S37
|t 0
|l Cushing: Theses & Dissertations Microforms (Does not check out)
|
| 998 |
f |
f |
|a 1997 Thesis S37
|t 0
|l Available Online
|