Regulation of insulin-like growth factor binding protein-4 in Ah responsive and Ah nonresponsive human breast cancer cells by 17 B-estradiol and 2,3,7,8 tetrachlorodibenzo-p-dioxin /
(Ah) nonresponsive cells (BaP MCF-7 and T47D5 cells) were
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| Format: | Thesis eBook |
| Language: | English |
| Published: |
[Place of publication not identified] :
[publisher not identified] ;
1997.
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| Subjects: | |
| Online Access: | Link to OAKTrust copy |
| Summary: | (Ah) nonresponsive cells (BaP MCF-7 and T47D5 cells) were (E2) induced IGFBP-4 protein secretion and MRNA expression affected 24 hours after treatment. Aryl-hydrocarbon receptor and these effects were decreased after co-treatment with 10 and wild-type cells, with the exception of IGFBP-5. IGFBP-4 caused a decrease in constitutive secretion of IGFBP-4, cells were not significantly different. These data support cells. In contrast, when detected by immunoblot analysis detected IGFBP-4 at 80 and 14-fold lower levels in the BaP expression. In human breast cancer cells, 17 O-estradiol factor binding protein-4 (IGFBP-4) protein secretion and MRNA however, the constitutive IGFBP-4 MRNA levels were not IGFBPs were secreted at similar levels in Ali nonresponsive MCF-7 and T47D5 cells, respectively compared to wild-type MRNA levels expressed in T47D, T47D5, MCF-7 and BaP MCF-7 nM TCDD. In MCF-7 human breast cancer cells, 10 nM TCDD regulation of IGFBP-4 by TCDD. Western ligand blot analysis tetrachlorodibenzo-p-dioxin (TCDD) on insulin-like growth the hypothesis that IGFBPs in the BaP MCF-7 and T47D5. This study focused on the effects of 2,3,7,8- utilized to investigate the role of the Ah-receptor in the |
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| Item Description: | "Major subject: Biochemistry". In title, Greek symbol Beta and numerals are used. Vita. |
| Physical Description: | xii, 113 leaves : illustrations ; 28 cm. Also available online. Issued also on microfiche from Lange Micrographics. |
| Bibliography: | Includes bibliographical references. |