Ovarian nitric oxide synthase gene expression during peripubertal development /
(p<0.01) and LH (p<0.001). The INOS protein levels
| Main Author: | |
|---|---|
| Format: | Thesis eBook |
| Language: | English |
| Published: |
[Place of publication not identified] :
[publisher not identified] ;
1997.
|
| Subjects: | |
| Online Access: | Link to OAKTrust copy |
| Summary: | (p<0.01) and LH (p<0.001). The INOS protein levels accompanied by preovulatory increases in serum estradiol analysis revealed both INOS and CNOS protein expression in associated with declining (p<0.05) serum levels of estradiol. before and after first ovulation; hence, suggesting a role both forms of NOS were expressed in the ovary and that the both the inducible (i) and constitutive (c) forms of NOS and change during the peripubertal period. Specifically, there donors in vitro, suggests that NO may be involved in ovarian dramatically increased again to peak on the morning of first during the early proestrous phase of development. By the during the late proestrous phase (p < 0. 05) which was each phase of puberty with only INOS showing a significant estrous and diestrous phases. Furthermore, Western blot estrus (p<0.001), i.e. a few hours after ovulation, an event examined in the present study whether the ovary expresses exogenously induced. Importantly, when compared with for NO in the ovary during pubertal maturation and function. However , neither the presence of NOS mRNA nor the functions, some of which are associated with reproduction. furthermore, providing compelling evidence at the gene level in the expression of ovarian INOS MRNA and protein both INOS MRNA transcripts were expressed without being interest in ovarian function at the time of puberty, we isoforms of the enzyme nitric oxide synthase. (NOS) and is juvenile levels, INOS, but not CNOS, MRNA increased (p<0.01) known to be involved in mediating several biological late proestrous phase, the levels of INOS MRNA declined markedly (p<0.001) and remained low throughout both the first Much attention has been given to discerning the role of the Nitric oxide (NO) is generated from L-arginine by different NOINOS system regarding hypothalamic-pituitary hormone phases of peripubertal development. Results indicate that physiological role in ovarian function. postovulatory events have been reported. Because of our potential change in NOS gene expression relating to pre- and presence or potential functions in the ovary- Recent data, secretions with less attention devoted to discerning its supporting the hypothesis that the NOINOS system plays a These data are the first to demonstrate developmental changes using NOS inhibitors both in vivo and in vitro, as well as NO was an initial increase in the expression of INOS protein whether either form undergoes changes in the ovary during the |
|---|---|
| Item Description: | "Major subject: Veterinary Anatomy". Vita. |
| Physical Description: | viii, 38 leaves : illustrations ; 28 cm. Also available online. Issued also on microfiche from Lange Micrographics. |
| Bibliography: | Includes bibliographical references. |