rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Modulation of colonic biomarkers by different types of dietary fat and fiber during tumorigenesis
  name:
    name part: Zhang, Wenji.
    role:
      role term: creator
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: xx
    date issued: 1997
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    extent: xii, 225 leaves : illustrations ; 28 cm.
  abstract: Maintenance of a healthy colonic epithelium is a delicate balance between cell birth, differentiation and death, which may be disrupted during the tumorigenic process. The effects of specific types of dietary fats (corn oil and fish oil) and fibers (cellulose and pectin) on cell proliferation, differentiation, and apoptosis in rat colon carcinogenesis were examined. The percentage of rats with adenocarcinomas was: corn/cellulose 75.6%; corn/pectin 63.6%; fish/cellulose 60.6%; fish/pectin 51.5%. No tumors were found in saline-injected control rats. In the model of dietary effect on colon tumorigenesis, both lectin DBA binding (differentiation marker) and apoptosis were better predictors of tumor development. Cell proliferation indices could detect the carcinogenic effect of AOM, but not the protective effect of fish oil/pectin. The carcinogenic effect of AOM was best represented by the ratio of cell proliferation vs apoptosis, which was higher in both proximal and distal with P <0.0 1 5 as compared to saline. Fish oil also resulted in a lower ratio of cell proliferation vs apoptosis as compared to corn oil in both proximal (P = 0.0001) and distal (P = 0.0003) colon. The combined effect of fat and fiber was best explained through apoptosis. Fish oil/pectin diet resulted in an increase of number of apoptotic cells per crypt column in both proximal and distal (P < 0.05), and an increase of apoptotic index in the distal colon (P < 0.05) as compared to the other three diets. Fish oil/pectin also resulted in the highest concentration of lumenal butyrate in both proximal and distal colon (P < 0.015). There was a site specific relationship between lumenal butyrate concentration and cell differentiation/apoptosis, which was positive (P < 0.05) in the proximal colon but there was no correlation in the distal colon. These data suggest that dietary fats and fibers may modulate colon carcinogenesis through apoptosis and cell differentiation, in addition to their effect on cell pr…
  note: by Wen-Chi Chang.
  note: Vita.
  note: "Major Subject: Nutrition".
  note: Issued also on microfiche from University Microfilms Inc.
  note: Includes bibliographical references: pages 127-160.
  note: Ph. D. Texas A&M University 1997.
  subject:
    topic: major nutrition
  identifier: 97-29170 UMI
  identifier: http://proxy.library.tamu.edu/login
  related item:
    location:
      url: http://proxy.library.tamu.edu/login
  record info:
    record content source: TXA
    record creation date: 971029
    record change date: 20190325093331.0
    record identifier: in00001377778