rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Isolation, sequencing, and the genomic organization of the reduced folate carrier gene in the murine system
  name:
    name part: Greer, Kimberly Ann.
    role:
      role term: creator
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: xx
    date issued: 1996
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    form: remote
    extent: vii, 78 leaves : illustrations ; 28 cm.
  abstract: administration of periconceptional supplemental folic acid.
  abstract: an average rate in the U.S. of 1 per 1000 live-births with
  abstract: and seven introns. The gene forms at least four splicing
  abstract: as an extension of exon 3a. Future studies will be initiated
  abstract: being investigated. The reduced folate carrier (RFC)
  abstract: between altered RFC function, folate supplementation, and the
  abstract: bifida and anencephaly. Neural tube defects (NTDS) occur at
  abstract: carbon transfers in critical biochemical pathways leading to
  abstract: compromise DNA synthesis and cellular proliferation,
  abstract: constructed. Utilizing this model system, correlations
  abstract: Defective closure of the neural tube during embryogenesis
  abstract: delivers 5-methyltetrahydrofolate from the folate receptors
  abstract: deriving sequencing primers from the known CDNA sequence of
  abstract: DNA synthesis. Alterations in the folate pathway could
  abstract: end, the genetic regulation of folate internalization is
  abstract: expression will be localized and a knock-out mouse
  abstract: for subcloning. An approximately 1OKb positive clone was
  abstract: gene in the mouse. Screening of a murine ES cell genomic
  abstract: genomic sequence was derived. The gene contains eight exons
  abstract: in relation to the folate binding proteins. The RFC variant
  abstract: internalization, we isolated and partially sequenced the RFC
  abstract: Intracellular folates are believed to be responsible for the
  abstract: library produced eight positive clones; three were selected
  abstract: occurrence of NTDs may be elucidated.
  abstract: potentially disrupting normal developmental events. To this
  abstract: rates. Several investigators have shown a marked decrease in
  abstract: reduction in NTDs due to their role in facilitating single-
  abstract: results in serious and common birth defects such as spina
  abstract: selected ethnic groups having higher or lower prevalence
  abstract: subcloned into pbluescript and has been divided into smaller
  abstract: subclones. Utilizing each subc[one independently, and
  abstract: the gene, followed by chromosome walking, 5.6Kb of the
  abstract: the occurrence and recurrence rates of NTDs with the
  abstract: the relationship between NTDs and aberrant folate
  abstract: to determine the tissue specific expression of the RFC gene
  abstract: to the cytoplasm of the cell. As a first step in defining
  abstract: variants with alternate exons located 5'of exons 1 and 5, and
  note: by Kimberly Ann Greer.
  note: "Major subject: Genetics".
  note: Vita.
  note: Also available online.
  note: Issued also on microfiche from Lange Micrographics.
  note: M.S. Texas A&M University 1996.
  note: Includes bibliographical references: pages 64-77.
  subject:
    topic: Major genetics
  identifier: https://hdl.handle.net/1969.1/ETD-TAMU-1996-THESIS-G74
  related item:
    location:
      url: https://hdl.handle.net/1969.1/ETD-TAMU-1996-THESIS-G74
  record info:
    record content source: TXA
    record creation date: 970630
    record change date: 20220103134704.0
    record identifier: in00001374832