Isolation and characterization of a cDNA for the beta subunit of chicken Thyroid-Stimulating Hormone /

after the detection of GH in circulation on day 19 of

Bibliographic Details
Main Author: Gregory, Charles Carter, 1971-
Format: Thesis eBook
Language:English
Published: [Place of publication not identified] : [publisher not identified] ; 1996.
Subjects:
Online Access:Link to OAKTrust copy
Description
Summary:after the detection of GH in circulation on day 19 of
and growth hormone (GH) during late embyonic and early post-
bases). Once a probe was developed, TSHP MRNA levels were
been isolated and
chain reaction (PCR) was implemented and a homologous CDNA
day 1. T3 levels increased significantly on post-hatch day I
embryonic development. The regulation of TSHP gene
expression around the time of hatch. Comparison of the CDNA
expression by T3 and thyrotropin releasing hormone (TRH) is
expression on embryonic day 19 and post-hatch day 1. In these
followed that pattern, with a sharp increase on post-hatch
for chicken TSHP and use this CDNA to characterize TSHP gene
frog. However, TSHO has not been isolated from any avian
frog) identified three highly conserved regions. Polymerase
had no effect.
hatch ages of chickens. In these experiments it was shown
hybridized to an RNA species of approximately 500 bases in
measured along with thyroxine (T,), triiodothyronine (T 3),
MRNA levels, while T3 had no significant effects. However,
on day I T 3 decreased levels of TSHP MRNA, while TRH
other tissues. This length corresponds with the length of
pituitary RNA samples alone; no signal was detected in the
sequence was produced. Tissue specificity of the CDNA probe
sequenced in many species including several mammals and the
sequences for TSHP from five species (four mammals and the
species. The objective of this study was to isolate a CDNA
studies we found that on embryonic day 19 TRH stimulated TSHP
that TSHO MRNA peaked on embryonic day 19 and T4 levels
The beta subunit of Thyroid Stimulating Hormone (TSHP) has
TSHP MRNA in other species (that range from 450 to 575
was analysed by Northern blot. The "P-labeled probe
was to test the effect of TRH or T3 on chicken TSHP gene
well documented in mammals. The objective of the next study
Item Description:"Major subject: Poultry Science".
Vita.
Physical Description:viii, 63 leaves : illustrations ; 28 cm.
Also available online.
Issued also on microfiche from Lange Micrographics.
Bibliography:Includes bibliographical references: pages 55-62.