The effect of solvent on matrix-assisted laser desorption ionization mass spectrometry /
analyte ions and decreases the amount of cation adducts found
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| Format: | Thesis eBook |
| Language: | English |
| Published: |
[Place of publication not identified] :
[publisher not identified] ;
1996.
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| Subjects: | |
| Online Access: | Link to OAKTrust copy |
| Summary: | analyte ions and decreases the amount of cation adducts found aprotic solvent are presented. It appears the addition of between the matrix and analyte in solution. In addition, a carried through the crystallization process of MALDI. To crystallization of the analyte and matrix affect the ion demonstrated and discussed. It was found that as the solvent desorption/ionization mass spectrometry (MALDI) has developed further explore the solvent induced interactions between the hydrogen/deuterium exchange for bradykinin was decreased as in the mass spectrum. Thus, water stabilizes the interaction into a useful analytical tool in the biological field. The ion yields. We found that factors other than the matrix and analyte, studies using the addition of water to an physical characteristics such as low surface tension, low polarity decreased the amount of exchange was increased in propose that the interactions of the matrix and analyte in Since its introduction in 1988, matrix-assisted laser solution stabilized or destabilized by the solvent are study using hydrogen/deuterium exchange using MALDI is the case of bovine insulin. Yet, the amount of the solvent polarity was decreased. to smaller crystal formation, resulting in higher MALDI ion viscosity, high density, and high vapor pressure would lead water to acetone increases the abundance of protonated work presented here focuses on the effect of solvent on MALDI yields. It was previously thought that solvents with yields. Our results do not support this. Instead, we |
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| Item Description: | "Major subject: Chemistry". Vita. |
| Physical Description: | xiii, 78 leaves : illustrations ; 28 cm. Also available online. Issued also on microfiche from Lange Micrographics. |
| Bibliography: | Includes bibliographical references: pages 74-77. |