Characterization of the Brucella abortus rfb gene locus and the role of O-antigen in the resistance to complement lysis and macrophage defense mechanisms /
BALB/c mouse model. The difference in attenuation among the
| Main Author: | |
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| Format: | Thesis eBook |
| Language: | English |
| Published: |
[Place of publication not identified] :
[publisher not identified] ;
1996.
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| Subjects: | |
| Online Access: | Link to OAKTrust copy |
| Summary: | BALB/c mouse model. The difference in attenuation among the bovine macrophages, revealed distinct differences in controlling extracellular and intracellular killing of DNA revealed interruptions within genes encoding proteins In Gram-negative organisms, the lack of 0-antigen expression invading organisms. The rfb mutants were equally sensitive killing mechanisms. macrophages represent two major host defense mechanisms may be due to pleiotropic effects. This data suggests that mutants which do not express detectable 0antigen on their of Brucella abortus with Tn5 generated several rough (rfb) on the lipopolysaccharide molecule produces a rough phenotype outer membrane surface. Initial sequencing of Tn5 flanking participates in 0-antigen biosynthesis. Complement and rfb mutants, and the inability to complement the mutation, sensitivity among the rfb mutants were also recorded in the sensitivity among the rib mutants. Similar differences in sensitivity to polymixin B, hydrogen peroxide, and murine and the survival of Brticella is controlled by intracellular to bovine complement. Bactericidal assays, including which is associated with attenuation. Transposon mutagenesis with homology to gene products of the r)$ locus which |
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| Item Description: | "Major subject: Veterinary Microbiology". Vita. |
| Physical Description: | ix, 61 leaves : illustrations ; 28 cm. Also available online. Issued also on microfiche from Lange Micrographics. |
| Bibliography: | Includes bibliographical references: pages 49-60. |