Cyclobutane amino acids and peptidomimetics, parallel catalyst screening for aziridination /
and how catalysts screening using high throughput screening
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| Format: | Thesis eBook |
| Language: | English |
| Published: |
[Place of publication not identified] :
[publisher not identified] ;
1996.
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| Subjects: | |
| Online Access: | Link to OAKTrust copy |
| Summary: | and how catalysts screening using high throughput screening aziridinating reagents available, we were interested in aziridination of olefins had previously been reported by aziridine. Repeatable large scale aziridination catalyzed by aziridines are versatile intermediates for syntheses of biologically important compounds, such as amino acids, catalyst screening for aziridination of olefins. Since catalyzed aziridination, since there are only two conclusions were formulated: the cyclobutane amino acids and conformational studies of cyclobutane amino acids and containing these acids. From the first project, the following demonstrate asymmetric syntheses of cyclobutane amino acids, describes how known preparations of various nitrogen ylides desirable. Copper and rhodium catalyzed asymmetric developing new nitrogen ylides. The aziridination section different temperatures. Preliminary results from the plates discovery of naturally occurring cyclobutane amino acids has Doyle's catalysts are optimized and reported. efforts to discover a catalytic system for aziridination are evidenced by CD and 2D NMR. The second project is parallel for asymmetric aziridination. Syntheses and conformational important in synthetic and medicinal chemistry. Recent in this study adapts an P-hairpin secondary structure, as incorporation of these compounds into designed indicates that Doyle's catalysts gave satisfactory yields of metal catalysts, ylides, substrates, and solvents at methodology. Microtitre plates were used to screen various mimics of these cyclobutane amino acids and an octapeptide others. High yields and high enantiomeric excess with the peptidomimetics, and conformational studies of the tripeptide peptidomimetics; and, (ii) parallel screening of catalysts peptidomimetics; Crystal structures of the tripeptide mimics raised considerable interest in the syntheses and biological show extended conformations; and, the octapeptide synthesized studies of nonnatural amino acids and peptide mimetics are studies of these types of compounds. This thesis will their derivatives can be synthesized and incorporated into This thesis describes two projects: (i) syntheses and ylides Phl=NTs and PhI=NNs have been obtained. For metal- |
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| Item Description: | "Major subject: Chemistry". Vita. |
| Physical Description: | xi, 156 leaves : illustrations ; 28 cm. Also available online. Issued also on microfiche from Lange Micrographics. |
| Bibliography: | Includes bibliographical references: pages 150-155. |