Theooretical and experimental analysis of laser interaction with prostatic tissue /
Several optical probes and an inverse algorithm were designed to determine the in vivo optical properties of the prostate for multi-wavelengths. These optical probes are small enough to be placed inside prostate transurethrally and will detect the spatially and spectrally resolved fluence rates. Fo...
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| Format: | Thesis Book |
| Language: | English |
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[Place of publication not identified] :
[publisher not identified] ;
1996.
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| Subjects: | |
| Online Access: | http://proxy.library.tamu.edu/login?url=http://proquest.umi.com/pqdweb?did=739667521&sid=1&Fmt=2&clientId=2945&RQT=309&VName=PQD |
| Summary: | Several optical probes and an inverse algorithm were designed to determine the in vivo optical properties of the prostate for multi-wavelengths. These optical probes are small enough to be placed inside prostate transurethrally and will detect the spatially and spectrally resolved fluence rates. Following a proper calibration procedure, the detected signal is then least-square fitted to the light diffusion equation which will produce both the absorption and reduced scattering coefficients. The calibration procedure for these optical probes requires the use of tissue-simulating standard phantoms with known optical properties. Typical photometric techniques for optical property measurements of turbid media were utilized to determine the optical properties of the standard phantoms and the results were compared. With these optical properties determined, both optical and thermal calculations were performed using the nonlinear finite element method (NFEM). The effects of temperature- and exposure time- dependent optical properties and blood perfusion rate on the final coagulation depth were investigated in this calculation. The results highly increased scattering in the coagulated region andimply that the nonuniform blood perfusion rate may prevent deeper lethal thermal damage. |
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| Item Description: | Vita. "Major Subject: Bioengineering". |
| Physical Description: | xvi, 147 leaves : illustrations ; 28 cm. Issued also on microfiche from University Microfilms Inc. |
| Bibliography: | Includes bibliographical references: pages 127-137. |