Mechanisms of lead transport in two intestinal epithelial cell lines /
absorption of ingested Pb into the systemic circulation.
| Main Author: | |
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| Format: | Thesis eBook |
| Language: | English |
| Published: |
[Place of publication not identified] :
[publisher not identified] ;
1996.
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| Subjects: | |
| Online Access: | Link to OAKTrust copy |
| Summary: | absorption of ingested Pb into the systemic circulation. absorption of Pb from the gastrointestinal tract into the and neurological systems. One of the best ways to prevent Arginine-Glycine-Aspartate (RGD), and induction of as the heavy metal has been used in society; however, Pb blood stream. Unfortunately, little is known about the Caco-2 cells we demonstrated that induction of demonstrated that Pb is extruded from the IEC-6 cells by epithelium. Using two established intestinal epithelial cell first report of the use of intestinal epithelial cell lines increased total cellular Pb content, suggesting that involves a potentially energy-independent pathway which may lines, IEC-6 and Caco-2, we studied the effects of means of an energy-dependent mechanism. Additionally, in mechanisms of Pb absorption through the intestinal metallothionein by overnight exposure to zinc resulted in an metallothionein by zinc on the total cellular accumulation of metallothionein sequesters Pb in the cytosol. This is the modifiers, blocking of integrins with the tripeptide of Pb uptake will provide potential methods to prevent the Pb. We have shown that the uptake of Pb into IEC-6 cells primary targets of Pb toxicity are the hematological, renal systemic Pb toxicity from an ingested source may be to reduce temperature, metabolic inhibitors, sulfhydryl group to study the absorption of Pb. Understanding the mechanisms Toxic effects of lead (Pb) have been recognized for as long toxicity is still a problem today in humans and animals. The utilize sulfhydryl groups and integrins. We have also |
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| Item Description: | "Major subject: Veterinary Anatomy". Vita. |
| Physical Description: | ix, 59 leaves : illustrations ; 28 cm. Also available online. Issued also on microfiche from Lange Micrographics. |
| Bibliography: | Includes bibliographical references. |