Effects of dietary fat, fiber and carcinogen on fecal diacylglcyerols in the rat /

(14:0, 17:0, and 16:0) contributed to 50% of the model and

Bibliographic Details
Main Author: Pickering, Jennifer Sharon
Format: Thesis eBook
Language:English
Published: [Place of publication not identified] : [publisher not identified] ; 1996.
Subjects:
Online Access:Link to OAKTrust copy
Description
Summary:(14:0, 17:0, and 16:0) contributed to 50% of the model and
1, which was 2.5 times higher with cellulose than pectin
a 2 x 2 x 2 factorial study (2 fats: corn oil 'I and fish
amount (P < 0.05). Fecal DAG was also examined as a possible
analysis. In the regression model, saturated fatty acids
and 24 weeks after injection of azoxymethane, feces were
carcinogen injection or a saline injection. At three weeks
carcinogen). Rats were provided with one of four
cell growth programs and, therefore, could play a role in the
collected from 10 rats/treatment (n = 80 total) and analyzed
containing DAG, with fish oil/cellulose having the highest
DAG mass and composition have not been reported. We designed
DAG may have predictive value as a tumor diagnostic marker.
data offer insight into a mechanism by which diet may modify
diagnostic marker for colon cancer using multiple regression
fatty acids (20:5n-3, 22:5n-3 and 22:6n-3) were detected in
fecal DAG of fish oil-fed animals relative to corn
Fecal diacylglycerols (DAG) are known activators of protein
fiber was observed at both time points for nmols of 17:0
for DAG mass and fatty acyl composition by combined TLC and
gas chromatography. Dietary fat had a significant effect on
had an inverse effect on colon cancer tumor development.
kinase C (PKC), which in turn modulate colonic epithelial
kinase C, may alter colonic mucosal cell proliferation, our
malignant transformation process. However, the effects of
oil; 2 fibers: pectin and 'Cellulose; with and without
oil(P<0.001). The most significant effect of fiber was on the
physiological modifiers such as diet and carcinogen on fecal
points. Greater amounts of long chain n-3 polyunsaturated
semipurified diets for 5 weeks and either administered a
Since the production of fecal DAG, an activator of protein
supplementation. A significant interaction between fat and
the fatty acyl composition and mass of fecal DAG, and that
the mol % of fatty acyl composition of fecal DAG at both time
the risk of colon cancer development.
These data show that fat, fiber and carcinogen can modulate
total production (nmol excreted/day) of DAG at time point #
Item Description:"Major subject: Nutrition".
Vita.
Physical Description:viii, 78 leaves ; 28 cm.
Also available online.
Issued also on microfiche from Lange Micrographics.
Bibliography:Includes bibliographical references.