Pharmacokinetics of cisapride in normal healthy cats and recommended oral dosing regimen /
-+ 3.16 hr) . All cats tolerated all doses with no apparent
| Main Author: | |
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| Format: | Thesis eBook |
| Language: | English |
| Published: |
[Place of publication not identified] :
[publisher not identified] ;
1996.
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| Subjects: | |
| Online Access: | Link to OAKTrust copy |
| Summary: | -+ 3.16 hr) . All cats tolerated all doses with no apparent (MRT) was 6.36 + 4.21 hr; and volume of distribution (Vdss) 16.59 ng/ml, MRT was 8.32 + 4.47 hr, and F was 29.0 + 22.6%. 24 hour fast. Blood samples were collected intermittently administration of a single dose and the bioavailability (F) adverse effects. Based on these data an oral dose of 1 mg/kg at steady state that lies within the published therapeutic cisapride concentration, Co, was 421.30 + 155.37 ng/ml; cisapride in cats following oral (PO) and intravenous (IV) clearance was 0.015 + 0.0067 ml/min*kg; mean residence time curves were subjected to standard pharmacokinetic analysis. Disposition parameters were compared between PO and IV Elimination half-life was similar for both the oral and for 36 hours following administration. Cats were studied in given every 8 hours should maintain an average concentration groups. Following IV administration, extrapolated peak intravenous dose. Cisapride was detected with an HPLC assay intravenous routes (T1/2(lv) = 5.19 + 3.77 hr, Tk(po) = 5.27 of the drug when administered as an oral capsule. 7 cats each pairs using a random crossover design in which a cat range for people. receiving an oral dose was paired with one receiving an The purpose of this study was to determine the disposition of validated for cat plasma. Drug concentration versus time was 4.50 + 1.36 ml/kg. Cmax for the oral capsule was 73.32 + were treated with either 1 mg/kg (IV) or 2 mg/kg (PO) after a |
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| Item Description: | "Major subject: Veterinary Medicine and Surgery". Vita. |
| Physical Description: | viii, 39 leaves : illustrations ; 28 cm. Also available online. Issued also on microfiche from Lange Micrographics. |
| Bibliography: | Includes bibliographical references. |