Mechanisms by which butter fat may be protective against colon carcinogenesis /
(P<O. 00 1 8) than either palm oil or corn oil in both
| Main Author: | |
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| Format: | Thesis eBook |
| Language: | English |
| Published: |
[Place of publication not identified] :
[publisher not identified] ;
1996.
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| Subjects: | |
| Online Access: | Link to OAKTrust copy |
| Summary: | (P<O. 00 1 8) than either palm oil or corn oil in both acid composition in cell membrane phospholipids and affected by diet, especially high intake of fat. Although amount of fat and the interaction. The P values were less amounts (5%, 7.5% and 15% by weight) of dietary fat on 1) assigned to one of nine experimental diet groups (3 different butter fat may be protective against experimentally induced carcinogenesis are still unknown, they may involve the colon (P<0.0008). The significant effect of amount of fats on colon carcinogenesis by decreasing precursors for colon.; The greater the amount of fat in the diet, the lower colonic cell proliferation; 2) fatty acid composition of consistent pattern was observed with PGE2 synthesis in both decreasing cell proliferation. different types (butter fat, palm oil and corn oil) and Duncan's Multiple Range Test. Butter fat resulted in a lower effect on fatty 'd composition of phospholipids in both the fat but not for the interaction. Total means of the type of fat groups or the amount of fat groups were separated by fats on PGE2 synthesis in the proximal (P<0.0239) and distal fatty acids of mucosal phospholipids. The significant effect higher levels of saturated fatty acids of mucosal labeling index (P<O. 000 1) and a lower proliferative zone linoleic acid (I 8:2n-6) resulted in higher levels of n-6 membrane phospholipids and prostaglandin synthesis. The membrane phospholipids; 3) prostaglandin (PGE2and PGI2) modulation of cell proliferation, fatty acid composition of Of all the cancers, colon cancer appears to be the most of type of fats on prostaglandin synthesis was shown with of variance was used to determine the effect of type of fat, or corn oil. There were significant effects of amount of PGE2only in the proximal colon (P<0.0387). Butter fat PGI2 synthesis was only in the distal colon (P<0.0027). The phospholipids, whereas the corn oil diet which is high in proliferation. Ninety male Sprague Dawley rats were randomly prostaglandin synthesis thus decreasing synthesis of PGE2and prostaglandin synthetic capacity to changes in colonic cell proximal and distal colon and PGI2 synthesis in the distal proximal and distal colon. The butter fat diet proximal and distal colon. The type of fat had a significant purpose of this study was to determine the effect of resulted in lower level of PGE2 production than either palm synthetic capacity of colonocytes and relate changes in fatty than 0.05 for the effects of the type of fat or the amount of the mechanisms by which dietary fats affect colon the production of prostaglandins. The data suggest that types of fat x 3 different amounts of fat). Two way analysis which is high in saturated fatty acid did not result in |
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| Item Description: | "Major subject: Nutrition". Vita. |
| Physical Description: | xi, 82 leaves : illustrations ; 28 cm. Also available online. Issued also on microfiche from Lange Micrographics. |
| Bibliography: | Includes bibliographical references. |