Amikacin pharmacokinetics and the effects of ambient temperature on the dosage regimen in ball pythons (Python reguis) /
(Python regius) at 25' C and 37' C was studied. Blood
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| Format: | Thesis eBook |
| Language: | English |
| Published: |
[Place of publication not identified] :
[publisher not identified] ;
1995.
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| Subjects: | |
| Online Access: | Link to OAKTrust copy |
| Summary: | (Python regius) at 25' C and 37' C was studied. Blood 17.64+3.52 ug/ml with a median elimination half-life of 6,604.5 minutes (4.5 days). The Cmax was 11.98+1.67 ug/ml 69,900+0.011 ug-min/ml; apparent volume of distribution at 90, 360, 720, 1,440, 2,880, 4,320, 5,760, and 8,640 minutes after administration of amikacin. A 28-day washout period amikacin concentrations did not reach the recommended peak amikacin serum concentration had not fallen below the and 13.87 + 2.61 ug/ml for snakes housed at 25'C and 37'C and mean residence time, 3,530+273.7 minutes. Mean serum another half-life, or 4.5 days, before trough concentrations bacteria for up to 6 days. Based on results of this study, concentrations for mammals (25 ug/ml). In addition, the concentrations were above the MIC50 of selected gram-negative curves following IC administration at both temperatures best differences among the snakes housed at 25'C and 37'C. Model Disposition of amikacin following intracardiac (IC) and fit a two-compartment open model. For snakes housed at 37'C for most bacteria. In this study, it would have taken independent parameters were area under the curve, intramuscular (IM) administration in twelve ball pythons occurred between each study. Drug concentration versus time of 2 ug/ml were achieved. or 6 days. However, snakes that received amikacin either IC or IM and housed at 25' C or 37' C, the serum amikacin pythons should produce serum concentrations above the MIC50 recommended trough concentrations (2 ug/ml) by 8,640 minutes respectively. There were no significant pharmacokinetic samples were collected by cardiocentesis at 0, 15, 30, 60, steady state, 410+106 ml/kg; clearance, 0.0360︢.009 ml/min/kg the Co, or extrapolated time zero concentration, was the mean amikacin dose (3.48 mg/kg) administered IM to ball |
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| Item Description: | "Major subject: Veterinary Physiology". Vita. |
| Physical Description: | viii, 39 leaves : illustrations ; 28 cm. Also available online. Issued also on microfiche from Lange Micrographics. |
| Bibliography: | Includes bibliographical references. |