Role of excitatory amino acids in MoMuLV-ts1 induced neurodegeneration /
The tsl virus, a temperature-sensitive mutant of Moloney
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| Format: | Thesis eBook |
| Language: | English |
| Published: |
[Place of publication not identified] :
[publisher not identified] ;
1995.
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| Subjects: | |
| Online Access: | Link to OAK Trust copy |
| Summary: | The tsl virus, a temperature-sensitive mutant of Moloney murine leukemia virus TB, produces hind-limb paralysis and immunodeficiency when injected into neonates of the FVBN strain of mice. Changes in levels of free amino acids are seen in tsl-infected mice when compared with controls. Alterations in the biochemical homeostasis of neurons and glial cells may produce the changes seen in excitatory amino acids. A secondary cytotoxicity may be produced by the neurotransmitter amino acids, glutamate and aspartate, possibly as a result of the metabolic changes that occur in astrocytes and microgfial cells in infected mice. The most severe neurodegeneration produced as a result of isl infection is seen in the central nervous system, specifically in neurons. |
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| Item Description: | Vita. "Major subject: Toxicology". In title, numerals are used. |
| Physical Description: | viii, 33 leaves : illustrations ; 28 cm. Also available online. Issued also on microfiche from Lange Micrographics. |
| Bibliography: | Includes bibliographical references. |