rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Mechanisms of action of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds
  title info:
    title: Mechanisms of action of two, three, seven, eight-tetrachlorodibenzo-p-dioxin and related compounds
  name:
    name part: Liu, Hong
    name part: 1964-
    role:
      role term: creator
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: xx
    date issued: 1994
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    extent: xvii, 162 leaves : illustrations ; 28 cm.
  abstract: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) inhibited insulin-
  abstract: like growth factor-I (IGF-I)- /insulin-induced proliferation
  abstract: of MCF-7 cells. TCDD did not affect the binding affinity of
  abstract: [1251]IGF-I for the IGF-I receptor but decreased the number
  abstract: of IGF-1-induced receptor binding sites (Bmax). In contrast,
  abstract: TCDD alone did not affect Kd and Bmax values for binding of
  abstract: [12511insulin to the insulin receptor (IR) but decreased the
  abstract: insulin-induced Kd value for IR-ligand binding and increased
  abstract: Bmax value in cells cotreated with TCDD and insulin. TCDD
  abstract: also inhibited insulin-induced c-fos protooncogene expression
  abstract: and phosphorylation of the IR. In this study, two classes of
  abstract: compounds, namely, 6-substituted 3,4-benzocoumarins and 2-
  abstract: substituted phenanthridinones were characterized as aryl
  abstract: hydrocarbon receptor (AhR) agonists/antagonists and as
  abstract: inhibitors of CYP IA I -dependent activity in rat hepatoma
  abstract: H411E and human breast cancer MCF-7 cells. Both classes of
  abstract: compounds bound to the AhR; however, there was no correlation
  abstract: between their AhR-binding affinities and CYPIAL induction
  abstract: potencies in H41IE cells. 6-t-Butyl-3,4-benzocoumarin and 2
  abstract: phenylphenanthridinone inhibited CYPL Al activity by suicide
  abstract: inactivation of the protein but did not act as AhR
  abstract: antagonists in this cell line. In contrast, these two
  abstract: compounds exhibited AhR antagonist activities and inhibited
  abstract: induction of CYPIA] gene expression by TCDD in MCF-7 cells.
  abstract: Thus, the effects of 6-substituted 3,4-benzocoumarins and 2-
  abstract: substituted phenanthridinones were cell line-dependent.
  abstract: lndolo[3,2b]carbazole (ICZ) is derived from the natural
  abstract: product indole-3-carbinol (13C) via acid catalysis and
  abstract: previous studies have reported that ICZ (and 13C) exhibit AhR
  abstract: agonist activities, namely, binding to the AhR and induction
  abstract: this study. Like TCDD and other AhR agonists, ICZ
  abstract: downregulated nuclear esttogen receptor (ER) and inhibited
  abstract: E2-induced progesterone receptor (PR) levels, vit-CAT
  abstract: activity, cell proliferation and [3H]thymidine with [3H]E2
  abstract: for rat uterine cytosolic ER. Thus ICZ is an unique compound
  abstract: which exhibits both AhR and ER agonist activities.
  note: by Hong Liu.
  note: Vita.
  note: "Major Subject: Toxicology".
  note: In title, symbols and numerals are used.
  note: Issued also on microfiche from University Microfilms Inc.
  note: Includes bibliographical references.
  note: Ph. D. Texas A&M University 1994.
  subject:
    topic: Major toxicology
  identifier: 95-20417 UMI
  identifier: http://proxy.library.tamu.edu/login
  related item:
    location:
      url: http://proxy.library.tamu.edu/login
  record info:
    record content source: TXA
    record creation date: 960625
    record change date: 20190325093128.0
    record identifier: in00001313875