Effects of acemannan on macrophages /

Acemannan is a O-(I,4)-linked acetylated mannan. It is the

Bibliographic Details
Main Author: Zhang, Linna, 1965-
Format: Thesis eBook
Language:English
Published: [Place of publication not identified] : [publisher not identified] ; 1994.
Subjects:
Online Access:Link to OAKTrust copy
Description
Summary:Acemannan is a O-(I,4)-linked acetylated mannan. It is the
activation over that induced by IFN-Y alone. The activation
alone was unable to exert any significant phenotypic change
biochemical and functional changes were expressed by
concentrations of IFN-Y, acemannan caused highly significant
effects. It is unclear how acemannan exerts this wide
exposed to acemannan in the presence or absence of suboptimal
function. However, in the presence of suboptimal
including acceleration of wound healing, inhibition of
increased surface adhesion molecule expression and surface
inflammation, immune stimulation, anticancer, and antiviral
is clear that activation of macrophages could play a role in
levels of interferon-y (IFN-y). It was found that acemannan
macrophage. Macrophages play a wide variety of roles and it
macrophages in vitro. A macrophage cell line, RAW 264.7 was
major constituent of the pulp of the aloe vera plant (Aloe
on macrophage morphology, surface molecule expression and
potent macrophage activating agent, but only in association
Protein changes. These studies confirm that acemannan is a
spreading and increased nitric oxide production. The
the effects described above. For this reason, studies were
to link all the biological effects of acemannan is the
undertaken to investigate the effects of acemannan on
variety of effects. One common cell, however, that appears
vera L.). It has several important therapeutic properties
was expressed by increased macrophage size, cytoplasmic
with a second signal such as provided by interferon-y.
Item Description:"Major subject: Veterinary Microbiology and Immunology".
Vita.
Physical Description:xii, 113 leaves : illustrations ; 28 cm.
Also available online.
Bibliography:Includes bibliographical references.