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| LEADER |
00000ctm a22000005a 4500 |
| 001 |
in00001309921 |
| 005 |
20190325093125.0 |
| 008 |
960620s1994 xx a b 000 0 eng d |
| 035 |
|
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|a (OCoLC)34960508
|
| 035 |
|
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|9 AHA8604AM
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| 037 |
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|a 95-20367
|b UMI
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| 040 |
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|a TXA
|c TXA
|d UtOrBLW
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| 049 |
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|a TXAM
|a TXAR
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| 099 |
|
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|a 1994
|a Dissertation
|a G731
|
| 100 |
1 |
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|a Graciani, Nilsa Raquel,
|d 1966-
|
| 245 |
1 |
0 |
|a Spectroscopic studies of the secondary structure of small peptides containing 4-(2-aminoethyl)-6-dibenzofuranpropanoic acid and synthesis of phosphomonoesters and phosphodiesters derived from the photohydrolysis of 2-methoxy-5-nitrophenyl substituted phosphotriesters /
|c by Nilsa Raquel Graciani.
|
| 264 |
|
1 |
|a [Place of publication not identified] :
|b [publisher not identified] ;
|c 1994.
|
| 300 |
|
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|a xvi, 158 leaves :
|b illustrations ;
|c 28 cm.
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
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|a unmediated
|b n
|2 rdamedia
|
| 338 |
|
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|a volume
|b nc
|2 rdacarrier
|
| 504 |
|
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|a Includes bibliographical references.
|
| 500 |
|
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|a Vita.
|
| 502 |
|
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|b Ph. D.
|c Texas A&M University
|d 1994.
|
| 500 |
|
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|a "Major Subject: Chemistry".
|
| 530 |
|
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|a Issued also on microfiche from University Microfilms Inc.
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| 520 |
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|a Simple amides and peptides containing the
|
| 520 |
|
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|a conformationally restricted unnatural amino acids 4-(2-
|
| 520 |
|
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|a arninomethyl)-6-dibenzoftiranethanoic acid (2) and 4-
|
| 520 |
|
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|a amino-6-dibenzofuranmethanoic acid (3) were studied by
|
| 520 |
|
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|a NMR and FT-IR to ascertain their hydrogen bonding and 0-
|
| 520 |
|
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|a sheet nucleation capabilities as well as to compare them
|
| 520 |
|
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|a to the nucleator 4-(2-aminoethyl)-6-
|
| 520 |
|
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|a dibenzofuranpropanoic acid (1). Neither 2 nor 3 are
|
| 520 |
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|a effective P-sheet nucleators. Water soluble peptides
|
| 520 |
|
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|a containing I were studied using CD, I D- and 2D-NMR
|
| 520 |
|
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|a techniques to determine the mechanism by which residue 1
|
| 520 |
|
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|a nucleates P-sheet structure formation. In solution, at
|
| 520 |
|
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|a pH 4-5, peptides containing hydrophobic residues or
|
| 520 |
|
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|a histidine in the i and i+3 positions exhibit a well-
|
| 520 |
|
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|a defined P-tum structure with the dibenzofuran ring of 1
|
| 520 |
|
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|a adopting a perpendicular conformation with respect to
|
| 520 |
|
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|a the plane of the strands. The dibenzofuran portion of 1
|
| 520 |
|
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|a interacts with either the hydrophobic side chains or the
|
| 520 |
|
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|a charged imidazole ring flanking it through a hydrophobic
|
| 520 |
|
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|a or 7E-cation-like interaction, thus forming a well-
|
| 520 |
|
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|a defined P-tum mimetic capable of propagating P-sheet
|
| 520 |
|
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|a structure through a portion of the attached peptide
|
| 520 |
|
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|a strands. This hydrophobic cluster also promotes the
|
| 520 |
|
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|a formation of a 15-membered ring hydrogen bonded
|
| 520 |
|
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|a conformation necessary for P-sheet nucleation. A
|
| 520 |
|
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|a potential photocleavable protecting group for the
|
| 520 |
|
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|a synthesis of
|
| 520 |
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|a phosphopeptides containing 1 was developed. Phosphotriesters
|
| 520 |
|
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|a composed of one or two 2-methoxy-5-nitrophenyl group(s) can
|
| 520 |
|
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|a be quantitatively photohydrolyzed in aqueous acetonitrile to
|
| 520 |
|
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|a yield the desired phosphodiester or phosphomonoester,
|
| 520 |
|
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|a respectively. Photohydrolysis occurs by attack of hydroxide
|
| 520 |
|
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|a at both the phosphoryl phoSDhorus and at the ipso-carbon in
|
| 520 |
|
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|a the triplet exited state of the 2-methoxy-5riitrophenyl
|
| 520 |
|
|
|a substituted phosphoesters.
|
| 650 |
|
4 |
|a Major chemistry.
|
| 856 |
4 |
1 |
|u http://proxy.library.tamu.edu/login?url=http://proquest.umi.com/pqdweb?did=741965341&sid=1&Fmt=2&clientId=2945&RQT=309&VName=PQD
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| 952 |
f |
f |
|p noncirc
|a Texas A&M University
|b College Station
|c Cushing Memorial Library & Archives
|s cush tdr
|d Cushing: Theses & Disserertations (Remote Storage: 2-3 day retrieval)
|t 0
|e 1994 Dissertation G731
|h Other scheme
|i unmediated -- volume
|
| 952 |
f |
f |
|a Texas A&M University
|b College Station
|c Electronic Resources
|s www_evans
|d Available Online
|t 0
|e 1994 Dissertation G731
|h Other scheme
|
| 998 |
f |
f |
|a 1994 Dissertation G731
|t 0
|l Cushing: Theses & Disserertations (Remote Storage: 2-3 day retrieval)
|
| 998 |
f |
f |
|a 1994 Dissertation G731
|t 0
|l Available Online
|